利福昔明干混悬剂保留灌肠辅助治疗小儿细菌性肠炎疗效观察

目的：探讨利福昔明干混悬剂保留灌肠辅助治疗小儿细菌性肠炎的疗效及安全性。方法：将82例细菌性肠炎患儿随机分为治疗组（n=41）及对照组（n=41）,对照组给予抗炎、补液、对症等常规治疗,治疗组在对照组的基础上给予利福昔明干混悬剂保留灌肠治疗,观察用药后临床效果及不良反应。结果：治疗组排便次数明显少于对照组（P=0.006）,临床表现（发热、腹泻、黏液血便等）及大便常规恢复时间明显短于对照组（分别为P=0.018、P=0.013）。在病程第3天采集患儿粪便进行常规检测,发现治疗组患儿恢复情况明显优于对照组（P=0.016）。治疗组治愈率95.3%,明显高于对照组的75%（P=0.026）。治疗过程治疗组及对照组均无未发现呕吐、皮疹等不良反应病例。结论：利福昔明干混悬剂保留灌肠治疗小儿细菌性肠炎效果较好且安全性高,值得在临床上推广。

Curative effects of rifaximin dry suspension agent retention enema in treating pediatric bacterial enteritis

Objective： To investigate the efficacy and safety of retention enema with rifaximin dry suspension in the treatment of children with acute bacterial enteritis. Methods： 82 children with bacterial enteritis were randomly divided into treatment group（ n = 41 ）and control group （n = 41 ）. The control group was given conventional treat- ment, including antibiotics, rehydration and the maintenance of homeostasis. While the treatment group was given rifaximin dry suspension retention enema besides the treatments used in the control group. Clinical effects and ad- verse reactions were observed. Results： The number of bowel movements in the treatment group was significantly less than that of the control group （ P = 0. 006 ）, clinical manifestations and stool recovery time was significantly shorter than the control group（P =0. 018, P =0.013）. Children with faeces collected in the course of three days for routine testing, found that the treatment group children recovery was significantly better than the control group （P =0.016）. In the treatment group the cure rate was 95.3%, significantly higher than 75% in the control group （P = 0.026）. In the course of treatment the treatment group and the control group had no cases of vomiting, rash and other adverse reactions. Conclusion： Rifaximin dry suspension retention enema to treat pediatric bacterial en-teritis has better safe worth in clinical practice.