| 早产儿血清铁蛋白和叶酸与维生素B12水平的变化及其临床意义 |
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| 引用本文： | 郑振文,李吉昌,张俊玲,郭山春. 早产儿血清铁蛋白和叶酸与维生素B12水平的变化及其临床意义[J]. 中国医药, 2011, 6(1): 115-116. DOI: 10.3760/cma.j.issn.1673-4777.2011.01.055 |
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| 作者姓名： | 郑振文 李吉昌 张俊玲 郭山春 |
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| 作者单位： | 山东省滨州市人民医院儿科,256610 |
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| 摘 要： | 目的 探讨早产儿血清铁蛋白、叶酸、维生素B12(贫血3项)的变化情况,以便及早采取干预措施,预防和治疗早产儿贫血.方法 完全随机选取住院的早产儿30例作为观察组,正常新生儿30例为对照组.采用电发光分析仪,分别对2组对象进行贫血3项检测和比较.结果 早产儿出生时血清铁蛋白为(159.2±83.2)μg/L,低于对照组的(334.4±150.5)μg/L,差异有统计学意义(P＜0.05);维生素B12(383.5±236.4)ng/L与对照组(502.4±168.8)ng/L比较差异亦有统计学意义(P＜0.01).2周后检测,早产儿叶酸与出生时比较有明显下降[(17.1±2.2)μg/L比(13.1±3.9)μg/L,P＜0.01],维生素B12(248.8±205.4)ng/L也有明显下降(P＜0.05);红细胞总数、血红蛋白以及红细胞平均压积亦明显下降(P＜0.05).结论 早产儿出生后体内血清铁蛋白和维生素B12处于低水平;叶酸、维生素B12水平随着日龄的增加逐渐减低.Abstract：Objective To investigate the level changes of serum ferritin, folacin and vitamin B12 in prematurity. Methods Thirty prematurities and 30 healthy newborn babies were were enrolled in this study. Serum ferritin, folacin and vitamin B12 were measured by using electroluminescence analyzer. Results The serum ferritin and vitamin B12 of prematurity were lower than those of normal newborn babies [( 159.2 ± 83.2) μg/L vs (334.4 ±150.5 ) μg/L, P ＜ 0.05; ( 383.5 ± 236.4 ) ng/L vs (502.4 ± 168.8 ) ng/L, P ＜ 0. 01]. Serum ferritin and vitamin B12 of prematurity decreased after 2 weeks[(17. 1 ±2.2)μg/L vs (13.1 ±3.9) μg/L, P＜0.01;(383.5 ±236.4)ng/L vs (248.8 ±205.4)ng/L, P ＜0.05]. Conclusions After birth, serum ferritin and vitamin B12 of prematurity are at a low level. Folacin and vitamin Bi2 decrease with the increase of age.
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| 关 键 词： | 贫血 血清铁蛋白 叶酸 维生素B12 婴儿,早产 |
Changes of serum ferritin, folacin and vitamin B12 in prematurity |
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| ZHENG Zhen-wen,LI Ji-chang,ZHANG Jun-ling,GUO Shan-Chun. Changes of serum ferritin, folacin and vitamin B12 in prematurity[J]. China Medicine, 2011, 6(1): 115-116. DOI: 10.3760/cma.j.issn.1673-4777.2011.01.055 |
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| Authors: | ZHENG Zhen-wen LI Ji-chang ZHANG Jun-ling GUO Shan-Chun |
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| Affiliation: | . (Department of Pediatrics, Binzhou People＇s Hospital, Shandong Province. Binzhou 256610, China) |
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| Abstract: | Objective To investigate the level changes of serum ferritin, folacin and vitamin B12 in prematurity. Methods Thirty prematurities and 30 healthy newborn babies were were enrolled in this study. Serum ferritin, folacin and vitamin B12 were measured by using electroluminescence analyzer. Results The serum ferritin and vitamin B12 of prematurity were lower than those of normal newborn babies [( 159.2 ± 83.2) μg/L vs (334.4 ±150.5 ) μg/L, P ＜ 0.05; ( 383.5 ± 236.4 ) ng/L vs (502.4 ± 168.8 ) ng/L, P ＜ 0. 01]. Serum ferritin and vitamin B12 of prematurity decreased after 2 weeks[(17. 1 ±2.2)μg/L vs (13.1 ±3.9) μg/L, P＜0.01;(383.5 ±236.4)ng/L vs (248.8 ±205.4)ng/L, P ＜0.05]. Conclusions After birth, serum ferritin and vitamin B12 of prematurity are at a low level. Folacin and vitamin Bi2 decrease with the increase of age. |
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| Keywords: | Anemia Serum ferritin Folic acid Vitamin B12 Infant,premature |
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