缺氧诱导因子1α和血管内皮细胞生长因子在非霍奇金淋巴瘤中表达的研究

目的 研究缺氧诱导因子1α(H1F-1α)、血管内皮细胞生长因子(VEGF)、微血管密度(MVD)在淋巴瘤患者淋巴结中的表达及其与淋巴瘤的关系.方法 采用免疫组化方法测定28例淋巴瘤患者及(试验组)27例淋巴结炎患者对照组淋巴结组织中的HIF-1α、VEGF、MVD表达.结果 试验组和对照组MVD、VEGF、HIF-1α水平差异有统计学意义分别为是(57.2±10.7)%比(38.3±11.2)%、(38.5±6.6)%比(21.3±6.3)%、(39.2±4.5)%比(24.5±4.8)%,均P＜0.05].结论 非霍奇金淋巴瘤患者淋巴结中HIF-1α、VEGF、MVD水平均较淋巴结炎患者增高,HIF-1α可能通过调节VEGF的水平从而促进新生血管的形成.

Abstract：

Objective To examine the expression of plasma hypoxia-inducible factor 1 alpha (HIF-1 α),vascular endothelial growth factor (VEGF) and microvessel density (MVD) of patients with NHL. Methods Totally 28 cases in NHL group( group A) and 27 cases in control one( group B) were enrolled. We examined the expression of HIF-1α, VEGF and MVD in tissue samples with immunohistochemical stain of two groups respectively.Results The levels of HIF-1α, VEGF and MVD in the two groups respectively with significant statistical difference. Conclusions The levels of HIF-1 α, VEGF and MVD in patients with NHL is higher than that of in lymphadenitis. It's possible that HIF-1α can promote MVD via adjusting VEGF level.

Study of plasma hypoxia-inducible factor 1 alpha and vascular endothelial growth factor expression in patients with non-Hodgkin's lymphoma

Objective To examine the expression of plasma hypoxia-inducible factor 1 alpha (HIF-1 α),vascular endothelial growth factor (VEGF) and microvessel density (MVD) of patients with NHL. Methods Totally 28 cases in NHL group( group A) and 27 cases in control one( group B) were enrolled. We examined the expression of HIF-1α, VEGF and MVD in tissue samples with immunohistochemical stain of two groups respectively.Results The levels of HIF-1α, VEGF and MVD in the two groups respectively with significant statistical difference. Conclusions The levels of HIF-1 α, VEGF and MVD in patients with NHL is higher than that of in lymphadenitis. It's possible that HIF-1α can promote MVD via adjusting VEGF level.