氧化亚氮联合米索前列醇用于哺乳期瘢痕子宫人工流产术的临床观察

目的 探讨氧化亚氮与米索前列醇并用于哺乳期瘢痕子宫人工流产术的临床效果.方法 将180例哺乳期瘢痕子宫早孕妇女采取随机数字表法分为氧化亚氮组65例、联合组60例,将要求直接施以负压吸引术者55例作为对照组.观察3组术中镇痛效果、宫颈松弛程度、手术时间、出血量、手术并发症的发生率.结果 与对照组比较,氧化亚氮组及联合组镇痛效果明显,联合组宫颈松弛度更佳,且手术时间最短,手术并发症的发生率最低宫颈松弛度:86.7%比35.4%、18.1%;手术时间:(2.8±2.0)min比(3.6±2.3)min、(4.9±2.2)min;出血量:(13.4±2.8)ml比(17.1±3.1)ml、(19.0±2.8)ml;P＜0.05].结论 氧化亚氮镇痛、米索前列醇扩张宫颈,两者联合既能明显减痛,又能降低哺乳期癜痕子宫人工流产手术的操作难度,减少并发症的发生.

Abstract：

Objective To study the effect of nitrous oxide inhalant combined with misoprostol preoperatively on induced abortion of cicatricial uterus. Methods One hundred and eighty pregnant women who were desirous of termination of pregnancy were randomly assigned to receive nitrous oxide in combination with miso-prostol preoperatively( combination group) , nitrous oxide( nitrous oxid group) or none( control group). The main outcomes were analgesic effect, cervical dilatation, the duration of the procedure, intraoperative blood loss, incidences of induced abortion syndrome and other complications. Results The analgesia efficacy in combination group and nitrous oxid group showed significant differences from control group. Compared with nitrous oxid group, combination group showed further cervical dilatation, less duration of the procedure and incidences of complication (P ＜0. 05). Conclusions Nitrous oxide inhalant in combination with misoprostol preoperatively has proved analgesia efficacy for induced abortion of cicatricial uterus, which decreases the difficulty of operation and the risk of complications.

Effect of nitrous oxide inhalant combined with misoprostol on induced abortion of cicatricial uterus

Objective To study the effect of nitrous oxide inhalant combined with misoprostol preoperatively on induced abortion of cicatricial uterus. Methods One hundred and eighty pregnant women who were desirous of termination of pregnancy were randomly assigned to receive nitrous oxide in combination with miso-prostol preoperatively( combination group) , nitrous oxide( nitrous oxid group) or none( control group). The main outcomes were analgesic effect, cervical dilatation, the duration of the procedure, intraoperative blood loss, incidences of induced abortion syndrome and other complications. Results The analgesia efficacy in combination group and nitrous oxid group showed significant differences from control group. Compared with nitrous oxid group, combination group showed further cervical dilatation, less duration of the procedure and incidences of complication (P ＜0. 05). Conclusions Nitrous oxide inhalant in combination with misoprostol preoperatively has proved analgesia efficacy for induced abortion of cicatricial uterus, which decreases the difficulty of operation and the risk of complications.