国产奈达铂联合氟尿嘧啶治疗晚期食管癌疗效观察

目的 观察国产奈达铂+氟尿嘧啶(5-Fu)方案治疗晚期食管癌的近期疗效和不良反应.方法 将55例食管癌患者,完全随机分为治疗组(28例)和对照组(27例).治疗组方案:奈达铂,80～100mg/m2,静脉滴注,d1;5-Fu,750～800 mg/m2,采用便携式泵持续静脉滴注,d1-5.对照组方案:顺铂,50 mg/m2,静脉滴注,d1-3;5-Fu的用法同治疗组,每4周重复1次,共4周期.结果 治疗组和对照组的有效率分别为57.7%(15/26)和36.4%(8/22),差异无统计学意义(P＞0.05).治疗组各度恶心呕吐的发生率均明显低于对照组(均P＜0.05);治疗组Ⅰ～Ⅱ度肾脏损害的发生率低于对照组(P＜0.05).结论 奈达铂+5-Fu治疗晚期食管癌的疗效不低于顺铂+5-Fu,且不良反应易于耐受,值得临床推广.

Abstract：

Objective To observe the short term efficacy and side effects of China-made nedaplatin (NDP)and fluorouracil (5-Fu) treating advanced esophageal carcinoma. Methods The therapeutic regimen for NDP group was NDP plus 5-Fu. The therapeutic regimen for control group was Cisplatin plus 5-Fu. Results The efficiency of NDP group was 57.7% (15/26) and the efficiency of the control group was 36.4% (8/22) (P ＞0.05).The rates of different nausea and vomiting in NDP group were significantly lower than those in control group ( P ＜0.05 ). The rate of renal toxicity low the control group( P ＜0.05 )Diarrhea of two group mostly Appeared Ⅰ-Ⅱ degree; The rate of Ⅰ-Ⅱ degree of leukopenia in the NDP group was higher than that in the control group( P ＞ 0.05 ).The rate of thrombocytopenia in the NDP group was higher than that in the control group( P ＞ 0.05 ). Conclusions The efficacy of NDP group is no lower than the control group. NDP group is easily tolerant to the side effect. It can be used widely in clinic.

The treatment of advanced esophageal carcinoma with nedaplatin and fluorouracil

Objective To observe the short term efficacy and side effects of China-made nedaplatin (NDP)and fluorouracil (5-Fu) treating advanced esophageal carcinoma. Methods The therapeutic regimen for NDP group was NDP plus 5-Fu. The therapeutic regimen for control group was Cisplatin plus 5-Fu. Results The efficiency of NDP group was 57.7% (15/26) and the efficiency of the control group was 36.4% (8/22) (P ＞0.05).The rates of different nausea and vomiting in NDP group were significantly lower than those in control group ( P ＜0.05 ). The rate of renal toxicity low the control group( P ＜0.05 )Diarrhea of two group mostly Appeared Ⅰ-Ⅱ degree; The rate of Ⅰ-Ⅱ degree of leukopenia in the NDP group was higher than that in the control group( P ＞ 0.05 ).The rate of thrombocytopenia in the NDP group was higher than that in the control group( P ＞ 0.05 ). Conclusions The efficacy of NDP group is no lower than the control group. NDP group is easily tolerant to the side effect. It can be used widely in clinic.