小汗腺螺旋腺癌一例

患者女，70岁。40年前发现左颈部、躯干出现数个皮肤肿物，10余年前手术切除数个，术后复发并增多，2个月前肿物出现持续性钝痛，10 d前左颈部肿物出现破溃。组织病理学检查见真皮内肿瘤细胞团块，中央为良性小汗腺螺旋腺瘤的成分，周边为恶性肿瘤成分，恶性肿瘤成分中细胞轻度异形伴透明变性。免疫组化显示，癌胚抗原和上皮膜抗原呈阳性表达。诊断为小汗腺螺旋腺癌。手术切除后1个月复发，3个月复发的肿瘤增多增大，并出现破溃，术后6个月死亡。

Eccrine spiradenocarcinoma: a case report

A 70-year-old female patient presented with several cutaneous masses on the left neck and trunk for 40 years. Some masses were removed by surgical operation more than 10 years prior to the presentation, but recurred subsequently along with an increase in lesion number. Persistent dull pain emerged at the lesion sites 2 months prior to the presentation and the masses on the left neck ulcerated 10 days prior to the presentation. Histopathology showed tumor cell clumps in the dermis with benign eccrine spiradenoma components in the centre region and carcinomatous components in the periphery. The carcinomatous components included slightly atypical cells and hyaline degeneration. Immunohistochemically, carcinoembryonic antigen and epithelial membrane antigen were observed in the tumor tissues. The case was diagnosed as eccrine spiradenocarcinoma. The masses were surgically removed, but recurred 1 month later, increased in size and number and ulcerated 3 months later, and the patient died 6 months after the surgery.