慢性荨麻疹患者粉尘螨变应原皮肤点刺反应与自体血清皮肤反应的关系

目的 探讨自体血清的自身反应和粉尘螨诱发的变态反应在慢性荨麻疹（CU）发病中的作用和相关性。方法 对831例CU患者同时进行自体血清皮肤试验（ASST）及粉尘螨皮肤点刺实验（SPT），对ASST与粉尘螨变应原阳性之间的相关性进行分析。结果 831例CU患者ASST和粉尘螨的总阳性率分别为51.74%和64.62%，ASST阳性组和阴性组粉尘螨SPT阳性率分别为56.52%和73.86%，两组差异有统计学意义（P < 0.05）。ASST阳性组中ASST阳性程度和粉尘螨SPT阳性程度呈负相关性（P < 0.05）。结论 自体血清皮肤反应和粉尘螨变应原诱发的变态反应均在慢性荨麻疹的发病机制中呈负相关，对CU患者同时进行变应原和ASST检测有助于临床分型和治疗。

Relationship between skin prick test reactivity to dermatophagoides farinae and autologous serum reactivity in patients with chronic urticaria

Objective To investigate the role of and relationship between reactivity to autologous serum and dermatophagoides farinae (Df) in the pathogenesis of chronic urticaria (CU). Methods Autologous serum skin test (ASST) and skin prick test (SPT) to Df were carried out in 831 patients with CU. The correlation between reactivity to autologous serum and Df was statistically analyzed. Results The positivity rate of ASST and SPT to Df was 51.74% and 64.62%, respectively in the 831 patients. SPT was positive in 56.52% of patients with positive ASST and in 73.86% of those with negative ASST (P ＜ 0.05). In patients with positive ASST, the degree of autologous serum reactivity was negatively correlated with that of reactivity to Df (P ＜ 0.05). Conclusions The skin reactivity to Df and autologous serum plays an important role in the pathogenesis of CU, and the degree of the reactivity to Df and autologous serum is negatively correlated. To conduct ASST and SPT simultaneously in patients with CU may favor the clinical classification and therapy of CU.