Angiodysplasia and von Willebrand's disease type IIB treated with estrogen/progesterone therapy. |
| |
Authors: | W D Chey W L Hasler P L Bockenstedt |
| |
Affiliation: | Division of Gastroenterology, University of Michigan Medical School, Ann Arbor 48109-0362. |
| |
Abstract: | The association between angiodysplasia and von Willebrand's disease was first reported in 1967. The cases reported to date have involved patients with type I and IIA von Willebrand's disease. We report a patient with type IIB von Willebrand's disease who suffered gastrointestinal bleeding attributable to gastric angiodysplasia. The patient underwent endoscopic electrocautery acutely and has been treated long-term with estrogen/progesterone therapy. She has suffered no recurrent gastrointestinal bleeding at over 11 months of follow-up. We suggest hormonal therapy as an alternative to repeated blood product transfusion or extensive surgical resection in patients with von Willebrand's disease and gastrointestinal bleeding from angiodysplasia. |
| |
Keywords: | arteriovenous malformations hereditary hemorrhagic telangiectasia hormone therapy gastrointestinal bleeding |
|