重症肌无力伴亚临床甲状腺病变（附31例报告）

目的探讨重症肌无力（myasthenia gravis,MG）与亚临床甲状腺病变并存的临床特点。方法对2009年1月至2010年5月总参谋部总医院（解放军309医院）MG治疗中心确诊的508例MG患者中伴亚临床甲状腺病变的31例患者的临床和实验室资料进行回顾性分析。结果 MG伴亚甲减（亢）患者中,女性、眼肌受累率高,年龄构成无明显特点。TSH〉10.0μU/ml较TSH〈0.1μU/ml伴发MG全身型发病率高。MG伴亚甲亢TSH均值TPOAb阳性组大于抗体阴性组,甲状腺激素小于抗体阴性组;MG伴亚甲减则相反。结论 MG伴亚临床甲状腺病变以眼肌为器官特异性;女性免疫更敏感;MG伴亚甲减较伴亚甲亢病情重;TPOAb对病情程度有影响。

Myasthenia gravis concomitant with subclinical thyroidism illness

Objective To study the clinical characteristics of myasthenia gravis concomitant with subclinical thyroidism illness.Methods A retrospective study was conducted of 31 patients of myasthenia gravis concomitant with subclinical thyroidism illness among the 508 patients of myasthenia gravis diagnosed at the General Hospital of General Staff from Jan 2009 to May 2010.Results Myasthenia gravis concomitant with subclinical thyroidism illness involved more females and ocular muscles.Age was not a relevant factor.The mean TSH of MG concomitant with subclinical hyperthyroidism was above that of MG concomitant with subclinical hypothyroidism.Conclusion The organ specificity of myasthenia gravis concomitant with subclinical thyroidism illness is eye muscles.Females are more sensitive.MG concomitant with subclinical hypothyroidism is more serious than when concomitant with subclinical hyperthyroidism.TPOAbs have influence on the disease.