糖尿病视神经病变磁共振扩散张量成像诊断价值探讨

目的探讨磁共振扩散张量成像(MR-DTI)在糖尿病视神经病变检查中的诊断价值。方法对15例(30眼)Ⅱ型糖尿病合并视神经病变的患者和15例健康成年人(对照组)分别行3.0TMR-DTI检查,研究糖尿病视神经病变组和对照组视神经各向异性(FA)、平均扩散系数(MD)、平行扩散系数(λ∥)、垂直扩散系数(λ⊥)值,进行组间比较。结果糖尿病视神经病变组视神经FA、MD、λ∥、λ⊥值分别为0.321±0.090、(1808±431)×10-6mm2/s、(2393±273)×10-6mm2/s、(1488±467)×10-6mm2/s;对照组视神经分别为0.585±0.020、(935±133)×10-6mm2/s、(1654±157)×10-6mm2/s、(1026±492)×10-6mm2/s。糖尿病视神经病变组与对照组相比,FA值明显降低(P=0.000),MD值、λ∥值、λ⊥值明显升高(P=0.000)。结论 MR-DTI在糖尿病视神经病变筛查中有一定的应用价值。

Study of magnetic resonance diffusion tensor imaging in diabetic optic neuropathy

Objective:To explore the value of magnetic resonance diffusion tensor imaging(MR-DTI) in diabetic optic neuropathy.Materials and Methods:Fifteen patients with bilateral diabetic optic neuropathy and 15 healthy subjects were recruited with optic nerve scann by 3.0 T-MR-DTI.The metrics of fractional anisotropy(FA),mean diffusion coefficient(MD),eigenvalue ∥(λ∥),and eigenvalue ⊥(λ⊥) values of diabetic optic nerve fibres were calculated and compared between the 2 groups.Results:FA,MD,λ∥,λ⊥ values of diabetic optic nerve fibres were 0.321±0.090,(1808±431)×10-6 mm2/s,(2393±273)×10-6 mm2/s,(1488±467)×10-6 mm2/s,respectively.They were 0.585±0.020,(935±133)×10-6 mm2/s,(1654±157)×10-6 mm2/s,(1026±492)×10-6 mm2/s in controls,respectively.The MD,λ∥,λ⊥ values were higher in affected nerve fibres(P=0.000),but FA value were lower than control nerve fibres(P=0.000).Conclusion:MR-DTI is useful in detecting diabetes optic neuropathy.