CEACAM1在胶质瘤中的表达与血管生成关系的研究

目的 检测癌胚抗原相关细胞黏附分子1（CEACAM1）和血管内皮生长因子（VEGF）在胶质瘤中的表达,探讨其与胶质瘤血管生成的关系.方法 以110例胶质瘤标本作为研究对象,40例正常脑组织作为对照,采用免疫组织化学技术,分别检测CEACAM1、VEGF蛋白和CD105标记的血管在不同分级胶质瘤中表达的关系.结果 CEACAM1、VEGF蛋白和CD105标记的血管密度在胶质瘤中表达的阳性率明显高于正常脑组织,且胶质瘤分级越高,CEACAM1、VEGF表达的阳性率越高,血管密度越高.胶质瘤中CEACAM1、VEGF和血管密度呈正相关.结论 CE＇ACAMl、VEGF蛋白在胶质瘤发生发展中具有重要作用,二者对CD105标记阳性的血管具有明显的促进作用.

The expression significance and relationship study Of CEACAMI and angiogenesis in glioma

Obiective To detect the expressions CEACAM1, VEGF and CD105 protein, and nvestigate their significance On angiogenesis in glioma. Methods The StUdyincluded 110 eases OfgliomaaSexperimental groupand 40 eases Of norreal brain tissues aS control group. We detected the expressions Of CEACAM1, VEGF and CD105 by using IHC. Results The expressions Of CEACAM1 andVEGF werehigherinthe experimental groupthan in control group. The mierovessel densily was hlgher in the experimental group. Their expressions were correlated with tumor grade. Positive correlation between CEACAM1 and VEGF,CEACAM1 and microvessel density,VEGF and mierovessel density were found in glioma. Conclusions Theex- pressionsOfCEACAM1 andVF -JEriotonly promote the occurrence and development, but also promote the angiogenesis in glioma.