瑞格列奈或格列吡嗪联合甘精胰岛素治疗初诊2型糖尿病的观察 |
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引用本文: | 石春晖,郦文琴. 瑞格列奈或格列吡嗪联合甘精胰岛素治疗初诊2型糖尿病的观察[J]. 现代保健, 2011, 0(5): 11-12 |
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作者姓名: | 石春晖 郦文琴 |
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作者单位: | 江苏丹阳市人民医院,212300 |
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摘 要: | 目的比较瑞格列奈或格列吡嗪联合甘精胰岛素治疗对初诊2型糖尿病患者降糖的疗效及对β细胞功能的影响。方法将笔者所在医院门诊初诊的2型糖尿病患者45例,随机分成瑞格列奈组(瑞格列奈+甘精胰岛素,n=23)和格列吡嗪组(格列吡嗪+甘精胰岛素,n=22)。结果两组治疗3个月后餐前和餐后的末梢血糖及HbA1c均较治疗前明显下降(P〈0.01)。结论瑞格列奈(1mg,3次/d)联合甘精胰岛素控制餐后血糖、HbA1c和改善胰岛β细胞分泌功能较格列吡嗪(5mg,1次/d)联合组更好。
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关 键 词: | 糖尿病 瑞格列奈 格列吡嗪 甘精胰岛素 |
Clinical observation of repaglinide or glipizide combined with glargine in the treatment of newly diagnosed type 2 diabetic patients |
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Affiliation: | SHI Chun -hui, LI Wen -qin.( Danyang City People's Hospital, Danyang 212300, China) |
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Abstract: | Objective The effects of repaglinide or glipizide combined with glargine on glucose metabolism and β - cell function were observed in the patients with newly diagnosed type 2 diabetes. Methods The 45 patients with newly diagnosed type 2 were randomly divided in to Repaglinide group ( Repaglinide + Glargine; n = 23 ) and Glipizide group (Glipizide + Glargine ;n = 22). Results The preprandial capillary blood glucose, postprandial capillary blood glucose and HbAlc in both groups after 3 -month treatment were significantly reduced as compared with those at baseline( P 〈 0.01 ). Conclusion The treatment with repaglinide (1 mg, tid) plus glargine was more efficient than glipizide (5 mg, qd ) plus glargine in improving β - cell functiou, ameliorating HbA1 c and postprandial blood, glucose excursions in patients with type 2 diabetes. |
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Keywords: | Diabetes Mellitus Repaglinide Glipizide Glargine |
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