糖尿病患者周围神经传导速度及其临床意义

目的探讨糖尿病患者周围神经传导速度的变化及其临床意义。方法应用日本光电MEB-2200型肌电／诱发电位仪，对56例临床上确诊为糖尿病的患者和30例健康人，进行了周围运动神经传导速度（MCV）及感觉神经传导速度（SCV）检查及研究。并进行对照分析。结果56例患者中MCV或SCV至少有一项异常者37例，占66％（37／56例）。其中正中神经异常率为35．7％（40／112侧），尺神经异常率为26．8％（30／112侧），腓总神经异常率为61．6％（69／112侧）。而临床上确诊有周围神经病变者仅为17．9％（10／56）。病程大于10年的糖尿病患者组MCV、SCV与健康人比较有统计学意义（P〈0．01）。异常率下肢高于上肢，且传导速度的改变呈双侧对称性并与病程有关。结论神经传导速度的测定对早期诊断糖尿病性周围神经病变（DPN）是有价值的。

Clinical study on peripheral nerve conduction velocities in diabetic patients

Objective To study the changes of peripheral nerve conduction velocity in diabetic patients. Methods Peripheral nerve conduction velocities (NCV) including motor nerves conductive velocity(MCV) and sensory nerve conductive velocity(SCV) of 56 diabetic patients and 30 healthy controls were determined by Neurofax MEB-2200 EPEMG system(Japan). The results were analyzed. Results It demonstrated that there were pathological changes of NCV in 37 cases(3756,66 %). The abnormal rate was 35.7 %(40112) in median nerve;26.8 %(30112) in ruler nerve and 61.6 %(69112) in common peroneal nerve. The definite clinical diagnostic rate of diabetic peripheral neuropathy was rison from 18 % to 66 %. The MCV and SCV was significantly in patients with diabetes over 10 years than that in controls(P < 0.01). The abnormal rate of lower limbs was higher than that of upper limbs. The changes of NCV were characterized bilateral symmetry in limbs of diabetic patients and the changes were associated with the diabetic course. Conclusion It demonstrates that the determination of NCV is valuable in early diagnosis for diabetic peripheral neuropathy.