| SSTF预处理对局灶性脑缺血再灌注大鼠抗氧化能力的作用 |
| |
| 引用本文： | 陈萌,赵淑敏,郑小影,孔祥玉.SSTF预处理对局灶性脑缺血再灌注大鼠抗氧化能力的作用[J].承德医学院学报,2009,26(3):239-241. |
| |
| 作者姓名： | 陈萌 赵淑敏 郑小影 孔祥玉 |
| |
| 作者单位： | 承德医学院,河北承德,067000 |
| |
| 基金项目： | 河北省科技厅、教育厅资助课题 |
| |
| 摘 要： | 目的:观察黄芩茎叶总黄酮(SSTF)预处理对局灶性脑缺血再灌注大鼠的保护作用及机制.方法:50只SD大鼠随机分成5组,假手术组,缺血再灌注组,SSTF预处理低、中、高剂量组.各组大鼠分别灌胃给药一周后,采用线栓法建立大脑中动脉栓塞模型,缺血2小时再灌注24小时后取血,分别检测血清中丙二醛(MDA)含量、超氧化物歧化酶(SOD)和乳酸脱氢酶(LDH)活力.结果:SSTF下预处理可不同程度的降低缺血再灌注导致的血清MDA、LDH的上升和SOD活力的下降(P<0.01);且中、高剂量SSTF的作用优于低剂量(P<0.05,P<0.01).结论:SSTF预处理可提高局灶性脑缺血再灌注大鼠的抗氧化能力.
|
| 关 键 词： | 黄芩茎叶总黄酮 预处理 缺血再灌注 超氧化物歧化酶 丙二醛 乳酸脱氢酶 |
EFFECTS OF SSTF PRETREATMENT ON ANTI-OXIDANT ABILITY OF FOCAL CEREBRAL ISCHEMIA REPERFUSION RATS |
| |
| CHEN Meng,ZHAO Shu-min,ZHENG Xiao-ying,et al.EFFECTS OF SSTF PRETREATMENT ON ANTI-OXIDANT ABILITY OF FOCAL CEREBRAL ISCHEMIA REPERFUSION RATS[J].Journal of Chengde Medical College,2009,26(3):239-241. |
| |
| Authors: | CHEN Meng ZHAO Shu-min ZHENG Xiao-ying |
| |
| Institution: | CHEN Meng,ZHAO Shu-min,ZHENG Xiao-ying,et al(Chengde Medical College,Hebei Chengde 067000,China) |
| |
| Abstract: | Objective:To investigate the protective effects and mechanisms of scutellaria baicalensis stemleaf total flavonoid(SSTF) pretreatment on cerebral ischemia reperfusion rats.Methods:50 SD rats were randomly divided into 5 groups:sham operation group,ischemia reperfusion group and low,middle,high SSTF dosage group(n=10) .The cerebral ischemia reperfusion rats model were made by suture method 1 week after the rats were lavaged with drugs respectively.The MDA content,SOD and LDH activity in serum were detected r... |
| |
| Keywords: | SSTF Pretreatment Ischemia reperfusion SOD MDA LDH |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
