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The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies
Authors:Fortunato Morabito  Massimo Gentile  Sonia Fabris  Serena Matis  Ernesto Vigna  Katia Todoerti  Monica Colombo  Anna G. Recchia  Sabrina Bossio  Laura De Stefano  Fiorella Ilariucci  Agostino Cortelezzi  Ugo Consoli  Iolanda Vincelli  Emanuela A. Pesce  Caterina Musolino  Stefano Molica  Francesco Di Raimondo  Antonino Neri  Manlio Ferrarini
Affiliation:1. Haematology Unit, A.O., Cosenza, Italy;2. Biotecnology Research Unit, Aprigliano (CS), ItalyContributed equally to the study.;3. Department of Clinical and Community Science, University of Milan, Milan, Italy;4. Haematology Unit, Foundation IRCCS Cà Granda‐Policlinico Hospital, Milan, Italy;5. SS di Diagnostica Molecolare IRCCS S. Martino‐IST, Genova, Italy;6. Laboratory of Pre‐Clinical and Translational Research, IRCCS‐CROB, Referral Cancer Centre of Basilicata, Rionero in Vulture (PZ), Italy;7. Scientific Division, IRCCS S. Martino‐National Cancer Institute, Genova, Italy;8. Biotecnology Research Unit, Aprigliano (CS), Italy;9. Haematology Unit, Maria Nuova Civil Hospital of Reggio Emilia, Reggio Emilia, Italy;10. Haematology‐Oncology Unit, Garibaldi‐Nesima Hospital, Catania, Italy;11. Haematology Unit, A.O., Reggio Calabria, Italy;12. GISL Trial Office, Modena, Italy;13. Haematology Unit, University of Messina, Messina, Italy;14. Haematology Unit AO, Catanzaro, Italy;15. Department of Clinical and Molecular Biomedicine, Section of Haematology, Ferrarotto Hospital, University of Catania, Catania, Italy
Abstract:
Keywords:chronic lymphocytic leukaemia     IGHV     ZAP70  flow‐cytometry  prognostic markers
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