Likelihood ratios for fetal trisomy 21 based on nasal bone length in the second trimester: how best to define hypoplasia? |
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| Authors: | W Cusick T Shevell L S Duchan C A Lupinacci J Terranova W R Crombleholme |
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| Institution: | St Vincent's Medical Center, Department of OB/GYN, Division of Maternal Fetal Medicine, Bridgeport, CT 06606, USA. wcusick@stvincents.org |
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| Abstract: | OBJECTIVE: To determine the best measure of fetal nasal bone hypoplasia for trisomy 21 risk assessment in the second trimester. METHODS: This was a prospective, observational study performed at a single institution between February 2003 and December 2005. Fetuses with nasal bone length recorded sonographically between 16 and 20.9 weeks and known karyotype were included. Definitions of nasal bone hypoplasia assessed included: non-visualized nasal bone, nasal bone < 10th percentile, nasal bone < 2.5th percentile, biparietal diameter/nasal bone ratio >or= 10 and >or= 11 and nasal bone multiples of the median (MoM)
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