| 病毒唑的合成新工艺 |
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| 引用本文： | 杨宝东,张宏森. 病毒唑的合成新工艺[J]. 黑龙江医药, 2004, 17(2): 122-123 |
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| 作者姓名： | 杨宝东 张宏森 |
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| 作者单位： | 哈药集团制药总厂,150086;哈药集团制药总厂,150086 |
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| 摘 要： | 目的：采用合成新工艺提高病毒唑的收率。方法：用肌苷为原料，经乙酰化后在双磷酸酯的作用下与1，2，4-三氮唑-3-羧酸甲酯缩合，再经氨解制得产品。结果：以肌苷计，总收率为48％。结论：该合成路线简单实用，易在生产中推广。
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| 关 键 词： | 病毒唑 肌苷 四乙酰核糖 |
| 修稿时间： | 2003-11-03 |
A New Sythesis of Ribavirin |
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| Yang Baodong Harbin Pharmaceutical Factory. A New Sythesis of Ribavirin[J]. Heilongjiang Medicine, 2004, 17(2): 122-123 |
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| Authors: | Yang Baodong Harbin Pharmaceutical Factory |
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| Abstract: | Objective:Using the new sythesis of Ribavirin to improve the yield.Method:Ino- sine was acetylated to tetracetylribofuranose,which was condensed with Me 1,2,4-trazole-3-car- boxylate b the aiding of bisphosphate.Then treated with NH_3 to give Ribavirin.Result:The over- all yield was 48% on the basis of inosine.Conclusion:This new synthesis route is simple and use- ful,can be easily realized in the wide production. |
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| Keywords: | Ribavirin Inosine Tetracetylrihofuranose |
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