| 血必净注射液细菌内毒素检查法的考察 |
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| 引用本文： | 王晓蕾,白林,陆璐,高翠苹.血必净注射液细菌内毒素检查法的考察[J].解放军药学学报,2007,23(2):150-151. |
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| 作者姓名： | 王晓蕾 白林 陆璐 高翠苹 |
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| 作者单位： | 解放军总医院,药检室,北京,100853;解放军总医院,药检室,北京,100853;解放军总医院,药检室,北京,100853;解放军总医院,药检室,北京,100853 |
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| 摘 要： | 目的 为保证血必净注射液的临床用药安全，探讨建立血必净注射液细菌内毒素检查方法。方法 按中国药典2005年版附录细菌内毒素检查法要求进行试验。结果 血必净注射液稀释6倍（浓度为0．167）及以上时，不干扰鲎试剂与细菌内毒素的凝胶反应。结论 细菌内毒素检查法可用于检测血必净注射液中的细菌内毒素。
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| 关 键 词： | 血必净注射液 鲎试剂 细菌内毒素检查 干扰试验 |
| 文章编号： | 1008-9926（2007）02-0150-02 |
| 收稿时间： | 2006-09-29 |
| 修稿时间： | 2006-11-17 |
Bacterial Endotoxin Test of Xuebijing Injection |
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| WANG Xiao-Lei,BAI Lin,LU Lu,GAO Cui-Ping.Bacterial Endotoxin Test of Xuebijing Injection[J].Pharmaceutical Journal of Chinese People's Liberation Army,2007,23(2):150-151. |
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| Authors: | WANG Xiao-Lei BAI Lin LU Lu GAO Cui-Ping |
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| Institution: | WANG Xiao-Lei, BAI Lin, LU Lu, GAO Cui-Ping (1.General Hospital of PLA, Beijing 100853 China) |
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| Abstract: | Aim To establish a method using tachypleus amebocyte lysate （TAL） for testing the bacterial endotoxin in Xuebijing Injection in order to ensure the safe clinic application of Xuebijing Injection. Methods The tests were conducted according to appendix IX E of Chp 2005. Results Neither inhibition nor enhancement was found in the bacterial endotoxin test after the drug （Potassium Sodium pehydroandroandrographolide Succinate for Injection 0. 167 mg·ml^-1） was diluted to 6. Conclusion Bacterial endotoxin test can be used for the detection of bacterial endotoxin in Potassium Sodium pehydroandroandrographolide Succinate for Injection. |
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| Keywords: | Xuebijing Injection Tachypleus Amebocyte lysate Bacterial Endotoxin test Inteferency Experiment |
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