| 甲基黄酮醇胺对家兔主动脉条~（45）Ca跨膜流动的影响 |
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| 引用本文： | 龙平, 阎超华,张明升,梁月琴,周尔凤.甲基黄酮醇胺对家兔主动脉条~（45）Ca跨膜流动的影响[J].山西医科大学学报,1994(4). |
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| 作者姓名： | 龙平 阎超华 张明升 梁月琴 周尔凤 |
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| 作者单位： | 山西省心血管病研究所 |
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| 摘 要： | 本文应用４５Ｃａ流动法研究甲基黄酮醇胺（Ｍｅｔｈｙｌｌａｖｏｎｌａｍｉｎｅ，ＭＦＡ）对兔主动脉条４５Ｃａ跨膜流动的影响。发现：ＭＦＡ（０．１ｍｍｏｌ／Ｌ）时间依赖性抑制氯化钾（８０ｍｍｏｌ／Ｌ）诱导的４５Ｃａ内流及净摄取的增加，并能抑制静息状态的４５Ｃａ外流，取消并翻转去甲肾上腺素（ＮＡ，１μｍｏｌ／Ｌ）降低兔主动脉条４５Ｃａ外流作用。提示：ＭＦＡ对经ＰＤＣ的钙内流有抑制作用，并有一定的抑制钙泵及阻断α－受体作用。
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| 关 键 词： | 甲基黄酮醇胺，主动脉，钙跨膜流动，钙通道阻滞剂，兔 |
Effects of methylflavonolamine hydrochloride on 45Ca
transmembranefluxes in rabbit aorta |
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| Long Ping et al.Effects of methylflavonolamine hydrochloride on 45Ca
transmembranefluxes in rabbit aorta[J].Journal of Shanxi Medical University,1994(4). |
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| Authors: | Long Ping |
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| Institution: | Dept.of
Pharmacology |
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| Abstract: | ffects of methylflavonolamine(MFA)on 45Ca
transmembrane flu-xes were studied in rabbit aortic smooth muscle
strips.MFA(0.1mmol/L)time-dependently inhibited the increase of
calcium influx and net upta-ke induced by KCl(80mmol/L).Meanwhile,MFA
inhibited resting 45Caefflux,and reversed the decrease of 45Ca effluX
in rabbit aorta inducedby noradrenaline(NA).The results showed that
MFA inhibited Ca2+influx through potential dependent Ca channel,It
suggests that MFAcan inhibit calcium pump and has a bloking effect no
alpha-receptor. |
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| Keywords: | Methylflavonolamine aorta Ca2+-flux calcium channe1 rabbits |
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