| Abstract: | Cerebrospinal fluid (CSF) IgG and IgA of
103 cases with disorders of the nervous system
without intracranial hemorrhage, CSF IgM of 63
and CSF IgG, IgA and IgM of 9 non-neurologic
surgery patients are determined.
Increased CSF IgG levels are helpful in the
diagnosis of inflammatory demyelinating disord-
ers of the nervous system and increased IgA
may also be helpful. CSF concentrated 10 times
by polyacrylamide may raise the CSF IgA
detection rate.
Although the CSF IgG/TP ratio is not a good
parameter for the diagnosis of inflammatory
demyelinating disorders of the nervous system,
dynamic observation of this parameter in in-
dividual cases helps the understanding of the
tendency of patients' clinical condition to im-
prove or worsen.
The mechanism of CSF immunoglobulin in-
creases in various neurologic (especially inflam-
matory demyelinating) disorders is discussed. |
