p53、MDM2、cyclin G在星形细胞瘤中的表达及与肿瘤分化和预后的关系

目的：分析p53、MDM2、cyclin G在星形细胞瘤中的表达及与肿瘤分化和预后的关系。方法：应用免疫组化S-P法对54例脑原发性星形细胞瘤中p53、MDM2、cyclin G的表达进行检测，对其中41例取得随访资料的肿瘤患者存活因素进行分析。结果：p53、MDM2表达在星形细胞瘤、间变型星形细胞瘤和多形性胶质母细胞瘤中差异有显著性（F=12．16，P〈0．01；F=1．89，P〈0．05）。星形细胞瘤中p53、MDM2、cyclin G表达率分别为61％、56％、63％。p53、MDM2、cyclin G表达标记指数随着肿瘤恶性程度的增加而逐渐增高。三者标记指数高的肿瘤预后差。结论：p53、MDM2、cyclin G过度表达与星形细胞瘤分化和预后密切相关，能够客观地反映肿瘤增生分化和恶性程度。可以作为判断星形细胞瘤分化和预后有价值的参考指标。

Expression of p53, MDM2 and cyclin G in astrocytoma and their relationship with cell differentiation and prognosis

Objective To investigate the expression of p53, MDM2 and cyclin G in astrocytoma and their relation with cell differentiation and prognosis. Methods Expression of p53, MDM2 and cyclin G in 54 cases of brain primary astrocytoma was detected with immunohistochemistry S-P method. Among 41 cases of tumor with follow-up date, surviving factors were analysed. Results There was significant difference in expression of p53 and MDM2 among astrocytomas, anaplastic astrocytomas and gliblastoma(F=12.16, P < 0.01; F=1.89, P < 0.05). The expression of p53, MDM2 and cyclin G in astrocytoma was 61%, 56% and 63%, respectively. The higher the expressed labeling index of p53, MDM2 and cyclin G in astrocytoma, the worse the prognosis. Conclusion The expression of p53, MDM2 and cyclin G is closely associated with cell differentiation and prognosis of the astrocytomas,which can objectively reflect the tumor proliferation, differentiation and the malignant degree of astrocytoma and can be used as a valuable indicator for the deciding the differentiation and prognosis of astrocytomas.