3种用药方案治疗幽门螺杆菌感染的成本-效果分析

目的:评价3种用药方案治疗幽门螺杆菌感染的成本-效果。方法:将150例幽门螺杆菌阳性的消化性溃疡患者随机分为3组,每组50例,分别服用兰索拉唑+克拉霉素+阿莫西林(A组)、雷贝拉唑+阿莫西林+甲硝唑(B组)、奥美拉唑+克拉霉素+阿莫西林(C组),疗程均为7d,比较临床疗效并进行成本-效果分析。结果:A、B、C3组成本分别为120.19、62.02、120.75元,幽门螺杆菌感染根除率分别为82%、92%、80%,成本-效果比分别为146.57、67.41、150.94;A、C组方案相对于B组方案的增量成本-效果比分别为523.50,440.50。结论:与其他2组方案比较,B组方案为治疗幽门螺杆菌感染的较佳方案。

Cost-Effectiveness Analysis of 3 Drug Regimes for Infection of Helicobacter Pylori

OBJECTIVE:To evaluate the cost-effectiveness of three drug regimes for infection of Helicobacter Pylori (Hp).METHODS:150 patients with peptic ulcer infected by positive Hp were randomly assigned to three groups.They were treated with Lansoprazole,Clarithromycin and amoxicillin (group A,n=50),Rabeprazole,amoxicillin and metronidazole (group B,n=50) or omeprazole,Clarithomycin and amoxicillin (group C,n=50),respectively with course of treatment as 7 days.The observation of clinical efficacy and analysis of co...