| 罗通定的合成 |
| |
| 引用本文： | 霍立,甘永军,沈毅,周辉,李勤耕. 罗通定的合成[J]. 中国医药工业杂志, 2012, 43(5): 323-325 |
| |
| 作者姓名： | 霍立 甘永军 沈毅 周辉 李勤耕 |
| |
| 作者单位： | 重庆医科大学,重庆,400016 |
| |
| 摘 要： | 盐酸小檗碱在对甲苯磺酸作用下得到去亚甲基小檗碱盐酸盐,再经O-甲基化、还原生成消旋四氢巴马汀,最后经(+)-二对甲基苯甲酰酒石酸拆分得到罗通定,总收率约25％.
|
| 关 键 词： | 罗通定 镇痛药 合成 |
Synthesis of Rotundine |
| |
| HUO Li , GAN Yongjun , SHEN Yi , ZHOU Hui , LI Qingeng. Synthesis of Rotundine[J]. Chinese Journal of Pharmaceuticals, 2012, 43(5): 323-325 |
| |
| Authors: | HUO Li GAN Yongjun SHEN Yi ZHOU Hui LI Qingeng |
| |
| Affiliation: | (Chongqing Medical University,Chongqing 400016) |
| |
| Abstract: | Rotundine was synthesized from berberine hydrochloride by reaction in the presence of p-toluenesulfonic acid to give demethyleneberberine hydrochloride,which was subjected to O-methylation and reduction followed by resolution with(+)-DTTA with an overall yield about 25%. |
| |
| Keywords: | rotundine analgesic drug synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
