红景天多糖对小鼠体内脾淋巴细胞转化反应及NK细胞活性的影响

首次选取西藏红景天中提取出的红景天多糖(RPPS),以环磷酰胺(Cy)复制出免疫功能低下小鼠模型,观察了RPPS对小鼠外周血白细胞总数、血红蛋白含量、胸腺重量以及细胞免疫功能的影响。结果表明,RPPS对小鼠外周血WBC及胸腺重量无显著影响,对外周血Hb含量在正常小鼠有降低作用,而在免疫低下小鼠则有提升作用。RPPS可促进正常小鼠脾淋巴细胞转化反应及NK细胞杀伤活性,同时又可使免疫受抑小鼠上述指标逆转.结果提示,RPPS为一种新的生物反应调节剂。

Effects of RPPS on lymphocyte transformation and NK activity in mice

Taking Radix Phodiolae polysac-charides (RPPS) which was extrated from Radix Phodiolae native to Tibet, and using the immunosuppresive mice model, induced with Cy (cyclophosphamide), this paper investigated effects of RPPS on the WBC numbers and Hb content of perpheral blood, thymus weight and cell-mediated immunity of mice. It was found that RPPS had no obvious effects on WBCnumbers and thymus weight, and could decrease the content of Hb in normal mice while it increased the content of Hb in immunosuppresive mice. RPPS not only could enhance lymphocyte transformation and NK activity in normal mice but also could reverse the decrease of the above indexes in immunosuppresive mice. The results suggested that RPPS be a new biological response modifier.