心力衰竭患者血浆脑钠肽和血清基质金属蛋白酶-9的变化

目的探讨心力衰竭患者血浆脑钠肽（BNP）和血清基质金属蛋白酶（MMP-9）的变化及其临床意义。方法采用ELISA法测定80例心力衰竭患者八院第2日清晨血浆BNP、MMP-9水平，用心脏彩色多普勒诊断仪测定其左室射血分数（LVEF）。测定20例同期健康体检者作为对照。结果心力衰竭患者血中BNP、MMP-9水平明显高于正常对照组，与心功能纽约分级（NYHA）程度呈正相关，与左室射血分数（LVEF）呈负相关。结论BNP、MMP-9水平可以作为诊断心力衰竭的一个很好的指标，能较好地反映心功能不全的严重程度和左室的功能。

Variation of Brain Natriuretic Peptide and Matrix Mmetalloproteianse-9 in Patients with Congestive Heart Failure

ObjectiveTo explore the variation and significance of brain natriuretic peptide (BNP) and matrix mmetalloproteinase-9 (MMP-9) in patients with congestive heart failure (CHF). MethodsThe study population consisted of 80 patients with congestive heart failure (CHF)and 20 patients with normal coronary. Plasma BNP and MMP-9 was measured by ELISA the next morning after admission, the left ventricular ejection fraction (LVEF) was measured by echocardiography. ResultsThe plasma BNP level and MMP-9 level in CHF group was higher than that control group; The level of BNP and MMP-9 were positively correlated with the classification of NYHA; the level of BNP and MMP-9 were negatively correlated with left ventricular ejection fraction(LVEF). ConclusionsPlasma BNP and MMP-9 levels increase significantly in patients with CHF, which suggests that BNP and MMP-9 play an important role in the pathophysiology of CHF. Serum BNP and MMP-9 levels can reflect the degree of heart failure and reflect left ventricular size and remodeling.