血清irisin水平与腹型肥胖成人体脂率相关

目的探索血清irisin水平与体脂率的关系。方法选取2011年4月至2012年8月入组的厦门莲前社区腹型肥胖（男性腰围≥90cm，女性≥85cm）居民1204名，所有受试者接受问卷调查、体格测量、生化指标及血清irisin的测定，采用生物电阻抗的方法测定体脂率。数据运用t检验、单因素方差分析及logistic回归等进行统计分析。结果1204名肥胖受试者中女性807例，男性397例，年龄（534-7）岁（35～65岁）。女性体脂率高于男性[（39±4）％比（26±4）％，t=-53．50，P〈0．05]，女性血清irisin水平亦高于男性[8．9（4．7—17．2）比7．6（4．0～14．4）肛∥L，t=-2．87，P〈0．05]。按血清irisin水平对受试者进行三分位分层分析，发现不同的血清irisin组间体脂率、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）差异有统计学意义（F=4．49、3．63、4．88，趋势P均〈0．05）。对体脂率进行分层分析，发现随着体脂率的增加，血清irisin水平增加（F=3．33，P〈0．05），进一步进行logistic回归分析发现，校正年龄、性别、体质指数（BMI）、腰围、体力活动、血压、吸烟饮酒、TG、TC、LDL—C、高密度脂蛋白胆固醇（HDL—C）、糖化血红蛋白（HbAlC）、空腹血糖（FPG）、稳态模型胰岛素抵抗指数（HOMA—IR）后，体脂率每升高一个百分比，血清irisin水平则增加13％（OR=1．13，95％CI：1．01～1．25，X^2=4．83，P〈0．05）。结论在腹型肥胖人群中血清irisin水平与体脂率有关。

Association of serum irisin levels with fat mass percentage in adults with abdominal obesity

Objective To investigate the association of serum irisin level with fat mass percentage. Methods A total of 1204 subjects with obesity（waist circumference： male /〉90 cm, female /〉85 cm） were recruited from Lianqian Community in Xiamen city from April, 2011 to August, 2012. All the participants received questionnaire survey, physical examination, blood chemistry tests and serum irisin levels measurement, and the fat mass percentage was measured by using a bioelectrical impedance analyzer. The data were analyzed using student-t test, ANOVA and logistic regression. Results Total of 807 women and 397 men with central obesity took part in the study, the age was （53±7） yrs（35 to 65 yrs）. A higher fat mass percentage and serum irisin levels were shown in women as compared with those in men （ （ 39±4）% vs （26±4）% and8.9/（4.7-17.2） μg/Lvs7.6（4.0-14.4） μg/L, t= -53.50, -2.87, both P 〈0. 05 ）. Serum irisin levels were correlated with fat mass percentage in total subjects. Fat mass percentage, serum total cholesterol （TC） and low density lipoprotein-eholesterol （LDL-C） levels increased as serum irisin levels increased by tertiles （F = 4.49, 3.63, 4. 88, all P for trend 〈 0. 05）. Serum irisin levels were increased as fat mass percentage increased by tertiles （ F = 3.33, P 〈 0. 05 ）. Logistic regression analysis showed that serum irisin levels were increase by 13% as fat mass percentage increased by one percent after all metabolic markers （such as age, sex, body mass index, waist circumference, physical activity, systolic blood pressure, diastolic blood pressure, current smoking and drinking, triglyeeride, TC, LDL-C, high density lipoprotein-eholesterol, glycated hemoglobin Ale, fasting blood glucose and homeostasis model of assessment for insulin resistence index） were adjusted （ OR = 1.13, 95% CI： 1.01 -1. 25, X2=4. 83, P 〈 0. 05 ）. Conclusions Serum irisin levels in obese adults were associated with fat mass percentage.