Antiproliferative activity of the non-myelotoxic antitumour agent of plant origin,Thaliblastine, on two human glioma cell lines

Summary The antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, Thaliblastine, on two human glioma cell lines is described. Thaliblastine was added once one day following start of culture; proliferation was monitored over 7 days. The anti-proliferative activity of Thaliblastine was strongly dependent on concentration and time of incubation. The ID₅₀ of Thaliblastine in T406 and GW27 glioma lines was 5.1 g/ml and 8.2 g/ml (7.0 M and 11.2 M), respectively.Abbreviation TBL Thaliblastine