| 6-甲氧基正丁苯酞在大鼠肝微粒体中的代谢研究 |
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| 引用本文： | 彭仕华,崔燕岩,周同惠. 6-甲氧基正丁苯酞在大鼠肝微粒体中的代谢研究[J]. 药学学报, 1996, 31(7): 539-542 |
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| 作者姓名： | 彭仕华 崔燕岩 周同惠 |
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| 作者单位： | 中国医学科学院,中国协和医科大学药物研究所分析室 |
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| 摘 要： | 报道了用GC/MS方法及衍生化技术研究6-甲氧基正丁苯酞(MBP)在大鼠肝微粒体中的代谢转化结果。6-甲氧基正丁苯酞在苯巴比妥(PB)诱导的大鼠肝微粒体中主要转化为3-羟基、γ-羟基取代物,6-羟基正丁苯酞与一个环氧化代谢产物。
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| 关 键 词： | 6-甲氧基正丁苯酞 GC/MS |
| 收稿时间： | 1995-11-29 |
STUDIES ON METABOLISM OF 6-METHOXY BUTYL PHTHALIDE BY RAT LIVER MICROSOMES |
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| SH Peng,YY Cui and TH Zhou. STUDIES ON METABOLISM OF 6-METHOXY BUTYL PHTHALIDE BY RAT LIVER MICROSOMES[J]. Acta pharmaceutica Sinica, 1996, 31(7): 539-542 |
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| Authors: | SH Peng YY Cui TH Zhou |
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| Abstract: | The in vitro biotransformation of 6-methoxy butyl phthalide (MBP) by phenobarbital induced rat liver microsomes was investigated by GC/MS and GC/MS with TMS derivatization. Three major metabolites of MBP were identified as 3-OH-MBP, 6-OH-butyl phthalide and γ-OH-MBP. A less polar metabolite was tentatively identified as an epoxidation product. |
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| Keywords: | GC/MS 6-Methoxy butyl phthalide |
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