药物性肝病70例临床分析

目的探讨药物性肝病的临床特点。方法对70例药物性肝病患者的用药史、临床表现、肝功能检查、临床分型以及治疗预后作综合判断。结果多种药物可引起肝损害,居前三位的依次为抗结核药(30.0%),中药或中草药(25.7%),抗风湿药及解热镇痛药(5.7%),药物发生的时间大多在1～8w,同种药物引起的肝损害发生时间长短不一,与机体对药物的代谢异常和特异性体质有关。临床类型主要为肝细胞损害型,其次是胆汁淤积和混合型。结论重视药物性肝病的诊断,及时积极的治疗能收到较好的效果。

Clinical analysis of 70 cases with drug-induced liver disease

Objective To investigate the clinical characteristics of drug-induced liver disease and the level of liver damage caused by drugs. Methods The history taking medication,clinical manifestation, liver function test, clinical classification and prognosis were analyzed comprehensively with retrospection review. Results Many drugs could induce liver diseases, among which the most chief drugs were antiuberculotic(30%), traditional Chinese medicine or Chinese formulated products(25.71%), antirheumatic medication and anti-inflammatory(5.71%). The latent period varied in 1-8 weeks. The time of causing liver damage was different by the same drugs because of the abnormal metabolism and the specific body constitutions. The most frequent clinical types were the hepatocellular damage type, the cholestasis type and the mixed type. Conclusion The importance of the diagnosis should be emphasized, and the energetic therapy can also make good effect.