| 印防己毒素对安定抑制刺激下丘脑诱发的升压反应的影响 |
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| 引用本文： | 张玉芹,马季骅,张培华. 印防己毒素对安定抑制刺激下丘脑诱发的升压反应的影响[J]. 中国冶金工业医学杂志, 1998, 0(5) |
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| 作者姓名： | 张玉芹 马季骅 张培华 |
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| 作者单位： | 武汉冶金科技大学生理教研室 |
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| 摘 要： | 目的：研究印防己毒素对安定抑制刺激下丘脑诱发的升压反应的影响。方法：家兔用氨基甲酸乙酯和氯醛糖混合静脉麻醉，三碘季铵酚制动，人工呼吸，静脉注射安定，侧脑室注射氟安定和印防已毒素观察对刺激下丘脑诱发的升压反应的影响。结果：静脉注射安定和侧脑室注射氟安定均可抑制上述诱发的升压反应，侧脑室应用γ－氨基丁酸受体阻断剂印防已毒素可基本消除静脉注射安定对这种诱发升压反应的抑制作用。结论：安定对刺激下丘脑诱发的升压反应的抑制作用与γ－氨基丁酸受体激活有关
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| 关 键 词： | 印防已毒素 安定 侧脑室注射 升压反应 γ-氨基丁酸受体 |
Enfluence of picrotoxin on diazepam inhibiting pressor response induced by hypothelamic stimulation |
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| Zhang Yuqin,Ma Jihua,Zhang Peihua. Enfluence of picrotoxin on diazepam inhibiting pressor response induced by hypothelamic stimulation[J]. Chinese Medical Journal of Metallurgical Industry, 1998, 0(5) |
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| Authors: | Zhang Yuqin Ma Jihua Zhang Peihua |
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| Affiliation: | Zhang Yuqin,Ma Jihua,Zhang Peihua.Department of physiology.Wuhan Yejin University of Science and Technology,Wuhan 430080 |
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| Abstract: | Objective:To study the enfluence of picrotoxin on diazepam inhibiting pressor response induced by hypothelamic stimulation.Methods:Experiment were performed on adult rabbits anesthetized with urethane and chloralose,paralyzed with flaxidil and ventilated artificially.Hypothelamic stimulation evoked the pressor,diazepam was injected into vein,diazepam and picrotoxin were injected into the ventricle of the brain.Results:Both intravenous injection of diazepam and intracerebroventricular injection of flurezepam inhibited the pressor response evoked by hypothelamic stimulation.The effect of diazepam intravenous injection were almost abolished by intracerebroventricular injection of GABA receptor antagonist picrotoxin.Conclusions:The inhibitory effects of diazepam on the pressor response induced by hypothelamic stimulation are related to the activation of GABA receptor in brain. |
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| Keywords: | Picrotoxin Diazepam Intracerebroventricular injection Pressor response GABA receptor |
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