| 缓释辅料对三七总皂苷缓释片中人参皂苷Rg1,Rb1释药特性的影响 |
| |
| 引用本文： | 吴清,陈贤春,杜守颖. 缓释辅料对三七总皂苷缓释片中人参皂苷Rg1,Rb1释药特性的影响[J]. 中国中药杂志, 2004, 29(10): 944-947 |
| |
| 作者姓名： | 吴清 陈贤春 杜守颖 |
| |
| 作者单位： | 北京中医药大学,中药学院,北京,100102 |
| |
| 摘 要： | 目的 :探讨缓释辅料对三七总皂苷缓释片中人参皂苷Rg1,Rb1释药特性的影响。方法 :通过考察由HPMC和EC 2种缓释辅料 ,不同黏度规格的EC ,以及EC的不同用量制成的缓释骨架片 ,测定人参皂苷Rg1,Rb1在这些缓释片中的释放度。结果 :缓释辅料的种类 ,规格及用量均影响人参皂苷Rg1,Rb1的释药特性 ,在各缓释片中人参皂苷Rg1,Rb1间的释药行为也存在差异。结论 :中药有效部位缓释制剂研究中应当重视有效成分间释药特性的异同。
|
| 关 键 词： | 三七总皂苷 缓释辅料 中药有效部位 释药特性 人参皂苷Rg1 人参皂苷Rb |
| 文章编号： | 1001-5302(2004)10-0944-04 |
| 收稿时间： | 2004-03-10 |
Effect of the sustained release excipients on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax notoginsenosides |
| |
| WU Qing;CHEN Xian-chun;DU Shou-ying. Effect of the sustained release excipients on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax notoginsenosides[J]. China Journal of Chinese Materia Medica, 2004, 29(10): 944-947 |
| |
| Authors: | WU Qing CHEN Xian-chun DU Shou-ying |
| |
| Affiliation: | Beijing University of Chinese Medicine, Beijing 100102, China. qwu@vip.sina.com |
| |
| Abstract: | Objective: To study the influence of the sustained release excipient on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax Notoginsenosides. Method : The release rate of ginsenoside Rg1 and ginsenoside Rb1 in differ ent matrix tablets with different excipient(HPMC, EC), different viscosity of EC(RT-50, RT-100), different ratio of EC in matrix tablet were detected. Result: All above different factors influence the release rate of ginsenoside Rg1 and ginsenoside Rb1 and brought them different release c urve. Conclusion: Emphasis should be laid on the different rel ease characteristic of different active compounds in active fraction. |
| |
| Keywords: | Panax notoginsenosides sustained release ex cipient active fraction release characteristic ginsenoside Rg 1 ginseno side Rb |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
