| 氧代赖氨酸与5—FU联合治疗肿瘤的实验研究 |
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| 引用本文： | 乐秀芳 吴富根. 氧代赖氨酸与5—FU联合治疗肿瘤的实验研究[J]. 中国医药工业杂志, 1989, 20(8): 360-362 |
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| 作者姓名： | 乐秀芳 吴富根 |
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| 作者单位： | 中国科学院上海药物研究所，中国科学院上海药物研究所，中国科学院上海药物研究所 上海 200031，上海 200031，上海 200031 |
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| 基金项目： | 中国科学院科学基金资助课题 |
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| 摘 要： | 氧代赖氨酸(I-677)的抗肿瘤作用是由于影响蛋白质的生物合成,本文将它与一些已知的影响核酸代谢的抗肿瘤药物用于联合治疗。发现与5-FU合用时能提高疗效。单用氧代赖氨酸(400mg/kg)ip 2次,或5-FU(25m/kg)ip 3次,对肉瘤37无抑制作用,合用时则产生显著的抑制效果。
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| 关 键 词： | 氧代赖氨酸 5－氟脲嘧啶 肿瘤 |
COMBINATION CHEMOTHERAPY TRIALS OF OXALYSINE WITH 5-FU IN EXPERIMENTAL ANIMAL TUMOR |
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| YUE Xiu-Fang,WU Fu-Geng,XU Bin. COMBINATION CHEMOTHERAPY TRIALS OF OXALYSINE WITH 5-FU IN EXPERIMENTAL ANIMAL TUMOR[J]. , 1989, 20(8): 360-362 |
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| Authors: | YUE Xiu-Fang WU Fu-Geng XU Bin |
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| Abstract: | Oxalysine reduced the content of fibrinogen in mice bearing solidtumor and inhibited the synthesis of histone in tumor cells. The effect of com-bination chemotherapy of oxalysine with other antitumor drugs, which inhibitedthe synthesis of nucleic acid, was studied. The results showed that treatment of mice bearing sarcoma 37 with oxaly-sine (400 mg/kg on days 1, 4) or 5-FU (25mg/kg on days 2, 5, 7) alone pro-duced only 10% and 27% inhibitory rate, respectively. Combination chemotherapywith the same treatment schedule increased the inhibitory rate to 43%.Suchresults might be meaningful for clinical trials. |
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| Keywords: | oxalysine 5-FU combination chemotherapy sarcoma 37 |
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