| 掌叶半夏碱甲及其衍生物的合成 |
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| 引用本文： | 耿培武 杨晓萍. 掌叶半夏碱甲及其衍生物的合成[J]. 中国医药工业杂志, 1989, 20(9): 388-391 |
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| 作者姓名： | 耿培武 杨晓萍 |
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| 作者单位： | 北京制药工业研究所，北京制药工业研究所，北京制药工业研究所，北京制药工业研究所 北京 100020，北京 100020，北京 100020，北京 100020 |
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| 摘 要： | 腺嘌呤(1a)与6-氯甲基吡啶衍生物(7a～c)在NaH/DMF中反应生成相应的6-氨基-9-(3-取代-6-吡啶)甲基-9H-嘌呤(3b～3d)。3c在酸性甲醇溶液中以Pd/c催化氢解得3a。3a～d的化学结构经光谱分析确证;其中3a为掌叶半夏碱甲。
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| 关 键 词： | 生物碱 掌叶半夏碱甲 衍生物 合成 |
SYNTHESIS OF PEDATISECTINE A AND ITS DERIVATES |
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| GENG Pei-Wu,YANG Xian-Ping,WEN Yao-Dong,WANG Pu-Shan. SYNTHESIS OF PEDATISECTINE A AND ITS DERIVATES[J]. , 1989, 20(9): 388-391 |
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| Authors: | GENG Pei-Wu YANG Xian-Ping WEN Yao-Dong WANG Pu-Shan |
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| Abstract: | 6-Amino-9- (3-subitituted-6-pyridinyl) methyl-9H-purines (3b-3d)were synthesized through reactions of adenine 1a with 6-chloromethylpyridines(7a~7c) in the presence of NaH/DMF. Compound 3a was obtained by catalytichydrogenolysis of 3c and elucidated to be identical with Pedatisectine A. The stru-ctures of compounds 3b, 3c and 3d were also identified by spectroscopic analyses. |
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| Keywords: | Pinellia Pedatisecta Schott alkaloid pedatisectine A adenine synthesis |
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