| 树突状细胞和小胶质细胞在脑胶质瘤自体免疫治疗中的作用机制 |
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| 引用本文： | 牛洪泉,王煜,董震,董芳永,柳再明,雷霆,薛德麟.树突状细胞和小胶质细胞在脑胶质瘤自体免疫治疗中的作用机制[J].华中科技大学学报(医学版),2005,34(6):655-658. |
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| 作者姓名： | 牛洪泉 王煜 董震 董芳永 柳再明 雷霆 薛德麟 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院神经外科,武汉,430030 |
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| 基金项目： | 教育部留学回国人员科研启动基金资助项目(教外司留[2002]247号) |
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| 摘 要： | 目的探讨树突状细胞（DC）和小胶质细胞（MG）在脑胶质瘤局部微环境＇中的关系及采用疫苗治疗后的变化。方法建立大鼠C6脑胶质瘤模型。采用C6细胞冻融抗原致敏DC制备疫苗，接种于造模第2天大鼠的皮下。以免疫组化法对大鼠脑内MG和DC的表达进行研究。结果治疗组DC表达均明显高于肿瘤组，而MG表达均明显低于肿瘤组。结论采用DC疫苗治疗可以增加局部微环境中的DC数量和改善免疫抑制状态，从而提高DC的功能。
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| 关 键 词： | 脑胶质瘤 免疫治疗 树突状细胞 小胶质细胞 |
| 修稿时间： | 2005年6月24日 |
Mechanism of Dendritic Cells and Microglias in Syngeneic Immunotherapy of Brain Glioma |
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| Niu Hongquan,Wang Yu,Dong Zhen et al.Mechanism of Dendritic Cells and Microglias in Syngeneic Immunotherapy of Brain Glioma[J].Journal of Huazhong University of Science and Technology(Health Sciences),2005,34(6):655-658. |
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| Authors: | Niu Hongquan Wang Yu Dong Zhen |
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| Institution: | Niu Hongquan,Wang Yu,Dong Zhen et alDepartment of Neurosurgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective To investigate the relationship between dendritic cells (DCs) and microglias (MGs) in the microenvironment of brain glioma and their changes after treatment of DC vaccine.Methods Rat C6 brain glioma model was constructed. DCs were immunized with C6 cell freeze-thaw antigen to prepare vaccine being subcutaneously inoculated into rats on the second day of modeling. By using immunohistochemical method, the presentation of DCs and MGs was detected.Results The presentation of DCs in treatment group was significantly higher, while MGs significantly lower than that in tumor group.Conclusion DC vaccine can increase the number of DCs and improve the local immunosuppressive state. |
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| Keywords: | brain glioma immunotherapy dendritic cell microglia |
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