Pharmacological correction of neurogenic disorders of cerebral circulation

The paper discusses the data on the effect of adrenergic innervation on the cerebral circulation and possible approaches to the pharmacological action on cerebral blood vessels constriction. Attention is also paid to the effect of alpha-adrenoblockers (dihydroergotoxin, phenoxybenzamine, phentolamine, etc) on adrenoreactive structures and of that of sympatholytics (reserpine, octadin, ornid) on the presynaptic membrane of the adrenoreceptor. Relaxation or elimination of cerebral vessels spasms was observed under the influence of the drugs capable of affecting the central component of cerebral circulation control. Drugs with central adrenergic (nialamide, nitroglycerin) and GABA-ergic (GABA, sodium hydroxybutyrate, depaquin, diazepam, phenazepam, etc) activity exerted the same effect.