Follow-up of men obtaining a six-core versus a ten-core benign prostate biopsy 7 years previously |
| |
Authors: | Clemens Brossner Stefan Madersbacher Phillip de Mare Anton Ponholzer Bader Al-Ali Michael Rauchenwald |
| |
Institution: | (1) Department of Urology and Andrology, Ludwig Boltzmann Institute for Urological Oncology, Danube Hospital, Langobardenstrasse 122, 1220 Vienna, Austria |
| |
Abstract: | The aim of this study is to evaluate the proportion of repeat biopsies after 7 years in men with an initial benign six- or
ten-core biopsy as well as the incidence of prostate cancer (PC) in the repeat biopsies. In this retrospective longitudinal
study, 116 men with an elevated prostate-specific antigen (PSA) and/or a suspicious digital rectal examination (DRE) who have
had a benign prostate biopsy between January 1997 and September 1997 were included. Fifty-eight men had an initial benign
six-core biopsy (median PSA 7.5 ng/ml, range 0.3–67) (group A), and 58 men had an initial benign ten-core biopsy (median PSA
7.5 ng/ml, range 0.8–91.4) (group B). We analysed men with a pathological PSA velocity, a persistently elevated PSA, an abnormal
DRE, a high-grade prostatic intraepithelial neoplasia or atypical adenomatous hyperplasia, or atypical small acinar proliferation
as indication for rebiopsy. Furthermore, we analysed a subgroup with exclusively an increased PSA velocity (>0.75 ng/ml per
year) as indication for rebiopsy. In group A, 14 men had a follow-up biopsy. In this group, follow-up biopsies yielded PC
in eight men (13.8%), six (10.3%) had a negative follow-up biopsy. In contrast, in group B only four men (3.4%) had a follow-up
biopsy (P=0.005). Two of them (3.4%) had PC (P=0.02), two cases (3.4%) showed a benign histology (P=0.06). The use of an extended biopsy protocol at the initial evaluation reduces the number of repeat biopsies required and
decreases the number of PC detection in the follow-up biopsy cohort. |
| |
Keywords: | Rebiopsies Biopsies Follow-up Longitudinal Prostate Rebiopsy |
本文献已被 PubMed SpringerLink 等数据库收录! |
|