Effects of rhG-CSF on Infection Complications and Impaired Function of Neutrophils Secondary to Chemotherapy for Non-Hodgkin's Lymphoma |
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Authors: | Yasuyuki Kuni-Eda Mihiro Okabe Mitsutoshi Kurosawa Isao Maekawa Masafumi Higuchi Michitsugu Kawamura Masanobu Morioka Sachiko Suzuki Takumi Ohmura Nozomi Fujimoto Kazuhiko Matsuno Kenzi Nakane Tomonori Minagawa Tamotsu Miyazaki Keisuke Sakurada |
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Affiliation: | a Third Department of Internal Medicine, Asahigawa Municipal Hospital, Hakodate, Japanb Asahigawa Municipal Hospital, Hakodate, Japanc Sapporo Municipal Hospital, Hakodate, Japand Hakodate Central Hospital, Hakodate, Japane Sapporo Aiiku Hospital, Asahigawa, Japanf Asahigawa Kousei Hospital, Asahigawa, Japang Wakkanai Municipal Hospital, Wakkanai, Japanh Kushiro Roosai Hospital, Kushiro, Japani Department of Clinical Laboratory, Hokkaido University School of Medicine, Sapporo, Japanj Department of Bacteriology, Hokkaido University School of Medicine, Sapporo, Japank Teisinn Hospital, Sapporo, Japan |
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Abstract: | It has been previously demonstrated that the administration of recombinant human granulocyte-colony stimulating factor (rhG-CSF) ameliorates the decrease of the polymorphonuclear neutrophils (PMNs) count after the cytotoxic chemotherapies, thereby reducing the infection complications associated with neutropenia. In this multi-center study, we studied the prophylaxtic effect of rhG-CSF administration on infection complications in patients with non-Hodgkin malignant lymphoma, who received cytotoxic chemotherapies (CHOP or ProMACE/CytaBOM). rhG-CSF administration reduced the frequency of infection complications, and there was no obvious difference in it's frequency between the CHOP-treated and the ProMACE/CytaBOM-treated groups when administered with rhG-CSF, thereby indicating that third generation therapy for NHL may be safely completed in Japanese in combination with rhG-CSF administration. Furthermore, we investigated both the in vitro and the in vivo effects of rhG-CSF on the function of PMNs in patients with NHL and healthy donors, and revealed that the administration of rhG-CSF for NHL patients receiving cytotoxic chemotherapy brought on an improvement of the production of active oxygen but did not affect serum levels of IFNs, IL-1 -(J, and IL-6, inspite of a slight elevation of TNF-a. Consistent with these results, in vitro treatment of PMNs with rhG-CSF induced no significant production of these inflammatory cytokines and their mRNA expressions. Furthermore, rhG-CSF administration showed no significant effects in vivo on the expression of CD1 la, CD1 lb and LECAM-1 on PMNs and integrins on platelets. |
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Keywords: | G-CSF malignant lymphoma neutrophil active oxygen inflammatory cytokines adhesion molecules |
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