重组人表皮生长因子凝胶与碘伏油纱治疗小面积Ⅱ度烧伤的比较

目的观察和比较重组人表皮生长因子（rhEGF）凝胶与碘伏油纱用于治疗小面积Ⅱ度烧伤的临床效果。方法95例小面积Ⅱ度烧伤患者,分成2组：其中使用rhEGF凝胶治疗的患者为rhEGF凝胶组,使用碘伏油纱治疗的患者为对照组,观察创面愈合时间、患者疼痛度、换药工作量及预后色素沉着情况并留取照片,1年后对部分患者进行随访。结果rhEGF凝胶组的治疗效果明显优于对照组。凝胶组的愈合时间【（9.82±1.52）d】明显短于对照组【（14.42±2.10）d】（P﹤0.01）,平均愈合时间提前3～5d;患者疼痛度明显减轻（VRS-5评分分别是：1.56±0.07和3.23±0.14,P﹤0.01）;换药工作量也明显缩小（治愈每1%TBSA所需要的时间分别是：（57.2±0.8）min和（84.9±4.3）min,P﹤0.01）;1年后部分患者随访证实凝胶组远期色素沉着较轻,并较少引起疤痕增生。结论rhEGF凝胶用于治疗小面积Ⅱ度烧伤效果确切,患者愈合时间缩短、疼痛度减小、换药工作量减少、预后色素沉着减轻,并且1年后随访发现多数患者效果良好。

Recombinant human epidermal growth factor gel in the treatment of partial-thickness burn

Objective To observe the effect of the recombinant human epidermal growth factor（rhEGF） in the treatment of partial-thickness burn.Methods Ninety-five cases of partial-thickness burn were randomly classified into 2 groups：rhEGF gel group and control group（PVP-I group）, the wound healing time, prognosis and collecting photographs were observed.Results The rhEGF gel group showed better effect than the control group.The healing time of the rhEGF gel group（9.82±1.52） d were shorter than the PVP-I group（14.42±2.10） d, and the average healing time was 3 to 5 d shorter with a statistical significance.Compared to the control group, the rhEGF gel group had less pain（score of VRS-5：1.56 ± 0.07 and 3.23 ± 0.14） and less doctor＇s workload（the time for curing 1%TBSA：（57.2±0.8）min and（84.9± 4.3）min.Some patients after 1 year follow-up confirmed less pigmentation.Conclusions RhEGF gel for the treatment of small area partial-thickness burns have exact effect, which could shorten the healing time, decrease the pain, reduce the doctors workload and the pigmentation.After 1 year follow, up most patients were found with good results.