双氯芬酸钠气雾剂的抗炎镇痛作用与毒性研究

目的：研究双氯芬酸钠气雾剂局部给药的抗炎镇痛作用及毒性反应。方法：采用醋酸扭体法、热板法和二甲苯致炎法，观察双氯芬酸钠气雾剂局部给药对小鼠的抗炎镇痛作用。观察家兔一次性口腔给药的急性毒性和滴眼给药的刺激性。多次给药对正常豚 鼠口腔粘膜及家兔损伤口腔粘膜的刺激性。结果：双氯芬酸钠气雾剂口腔给药，明显抑制小鼠醛酸扭体反应和热板舔足反应（P＜0.05)。局部喷雾给药，对小鼠耳肿胀度有明显抑制作用（P＜0.01)。一次或多次口腔及滴眼给药，未见明显毒性反应和刺激性。结论：双氯芬酸纳气雾剂局部给药，具有明显的抗炎镇痛作用，对家兔和豚鼠无 明显毒性和刺激性。

The antiinflammatory and analgesic effects and toxicity of aerosol diclofenac sodium on animals

Objective: To research into the antiinflammatory and analgesic effects and toxicity of aerosol diclofenac sodium (ADS) on animals. Methods: The antiinflammatory and analgesic effects of ADS on mice were studied by acetic acid inducing writhing model, hot plate method and dimethylbenzene inducing ear oedema model. The acute toxicity in a single intraoral dose of ADS and intraocular irritation were observed in rabbits. After multiple intraoral doses, the irritations of ADS on the normal guinea pigs' and traumatic rabbits' oral mucosa were evaluated. Results: When ADS was administered intraorally, the writhing reaction induced by acetic acid was inhibited and the pain threshold induced by hot plate was raised significantly in mice (P<0 05 and P<0 01). The swelling degree of ear was inhibited significantly by local ADS painting (P<0 01). The toxicant and irritant symptoms after single or multiple local administrations of ADS were not observed. Conclusion: ADS possesses significant antiinflammatory and analgesic effects in mice and the toxicity and irritation were not significant in guinea pigs and rabbits with local dosing.