脑溢安颗粒剂对急性脑出血患者肿瘤坏死因子、胰岛素抵抗的影响

目的 :观察脑溢安颗粒剂对急性脑出血患者血TNF α ,IR的影响。方法 :将 6 0例急性脑出血患者分为治疗组和西药对照组 (各 30例 ) ,采用放射免疫法测定其治疗前后的TNF α ,Insulin ,并与 15例正常人作对照。结果 :急性脑出血患者TNF α显著高于正常对照组 (P <0 .0 1) ,胰岛素敏感指数 (ISI)显著低于正常对照组 (P <0 .0 1) ;治疗后治疗组TNF α显著降低 (P<0 .0 1) ,ISI显著升高 (P <0 .0 1) ;两组TNF α,ISI与西药对照组比较差异有显著性 (P <0 .0 5～ 0 .0 1)。结论 :脑溢安颗粒剂降低脑出血患者TNF α、提高ISI是减少脑缺血再灌注损伤的机制之一

Effects of nao-yi-an on tumor necrosis factor alpha and insulin resistance of acute intracerebral hemorrhagic patients

Objective To investigate the effects of nao yi an on tumor necrosis factor alpha (TNF α) and insulin resistance of acute intracerebral hemorrhagic patients. Methods The patients were randomly divided into two groups: the medicine control group and the nao yi an treatment group. TNF α and insulin were checked by radioimmunoassay before and after the treatment. Fifteen healthy people were made as the negative control group. Results TNF α of both treatment groups was higher while isulin sensitivity index(ISI) was remarkably lower compared with the health group (P<0.01). After the treatment ISI increased and TNF α was remarkably lower in the treatment group (P<0.01). Differences of TNF α and ISI between the treatment group and medicine control group were significant (P<0.05 or P<0.01). Conclusion nao yi an can decrease TNF α and increase ISI, which is a mechanism of reducing cerebral ischemic reperfusion injury.