| P2X_7受体在新生大鼠缺氧缺血性脑损伤后表达下调 |
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| 引用本文： | 王丽雁,蔡文琴,陈鹏慧. P2X_7受体在新生大鼠缺氧缺血性脑损伤后表达下调[J]. 第三军医大学学报, 2009, 31(22): 2171-2174 |
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| 作者姓名： | 王丽雁 蔡文琴 陈鹏慧 |
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| 作者单位： | 第三军医大学基础医学部神经生物教研室,重庆市神经科学研究所,重庆,400038;第三军医大学新桥医院儿科,重庆,400037;第三军医大学基础医学部神经生物教研室,重庆市神经科学研究所,重庆,400038 |
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| 摘 要： | 目的 了解P2X_7受体在新生大鼠缺氧缺血型脑损伤后的表达变化.方法 选择出生7 d的SD大鼠建立新生鼠缺氧缺血性脑损伤模型,通过Western blot和免疫组化检测缺氧缺血前后脑皮层、白质、海马P2X_7受体表达.结果 缺氧缺血后2 h,患侧皮层、白质和海马P2X_7受体蛋白较假手术对照组明显下调(P<0.05,P<0.01);免疫组化也显示患侧皮层、白质和海马P2X_7,受体表达下降.结论 P2X_7受体可能参与了新生鼠缺氧缺血性脑损伤过程.
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| 关 键 词： | P2X_7受体 缺氧缺血 脑损伤 大鼠 |
Downregulation of P2X_7 receptor expression in neonatal rats after hypoxic-ischemic brain damage |
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| WANG Li-yan,CAI Wen-qin,CHEN Peng-hui. Downregulation of P2X_7 receptor expression in neonatal rats after hypoxic-ischemic brain damage[J]. Acta Academiae Medicinae Militaris Tertiae, 2009, 31(22): 2171-2174 |
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| Authors: | WANG Li-yan CAI Wen-qin CHEN Peng-hui |
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| Affiliation: | WANG Li-yan1,2,CAI Wen-qin1,CHEN Peng-hui1(1Department of Neurobiology,College of Basic Medical Sciences,Third Military Medical University,Chongqing 400038,2Department of Pediatrics,Xinqiao Hospital,Chongqing 400037,China) |
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| Abstract: | Objective To investigate the change of P2X7 receptor expression in neonatal rats after hypoxic-ischemic brain damage(HIBD).Methods Twenty SD rats were randomized into 2 groups,control group and hypoxic-ischemic(HI) group.Western blotting and immunohistochemistry was used to detect the protein expression of P2X7 receptor in cerebal cortex,subcortical white matter and hippocampus before and after hypoxia-ischemia.Results In comparison to the sham operation controls,a significant down-regulation of the P2X7 re... |
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| Keywords: | P2X_7 receptor hypoxia-ischemia brain damage rats |
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