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Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications
Authors:Papathomas Thomas G  Venizelos Ioannis  Dunphy Cherie H  Said Jonathan W  Wang Michael L  Campo Elias  Swerdlow Steven H  Chan John C  Bueso-Ramos Carlos E  Weisenburger Dennis D  Medeiros L Jeffrey  Young Ken H
Institution:
  • a Department of Pathology, Hippokration General Hospital of Thessaloniki, 54642 Thessaloniki, Greece
  • b Department of Pathology, Erasmus MC University Medical Center Rotterdam, 3015 GE Rotterdam, The Netherlands
  • c Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
  • d Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
  • e Department of Myeloma/Lymphoma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
  • f Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, 08014 Barcelona, Spain
  • g Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
  • h Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
  • i Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
  • Abstract:Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified with the advent of molecular genetic techniques, this topic has only rarely been a specific focus of the medical scientific literature. In this review, we focus on mantle cell lymphoma occurring as a major pathologic component of composite lymphoma and emphasize the clinicopathologic features of these tumors and associated biologic implications. To date, 26 cases of composite lymphoma including a component of mantle cell lymphoma have been previously published. Issues of clonal relatedness between the individual lymphoma components and emerging biologic implications as well as potential diagnostic pitfalls are evaluated.
    Keywords:Mantle cell lymphoma  Composite lymphoma  Clonal relationship  Small lymphocytic lymphoma  Chronic lymphocytic leukemia  Follicular lymphoma  Plasma cell neoplasm  Marginal zone lymphoma  Classical Hodgkin lymphoma  Plasmablastic lymphoma  Burkitt lymphoma
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