Comparison of half-dose versus half-fluence versus standard photodynamic therapy in chronic central serous chorioretinopathy |
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| Affiliation: | 1. Saglik Bilimleri University Fatih Sultan Mehmet Training and Research Hospital, Ophthalmology Department, 34752, Atasehir, Istanbul, Turkey;2. Medicana Camlica Hospital, 34692, Uskudar, Istanbul, Turkey;3. Atakoy Dunyagoz Hospital, 34158, Bakirkoy, Istanbul, Turkey;4. Bahcesehir University, Faculty of Medicine, 34734, Kadikoy, Istanbul, Turkey;1. University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey;2. Boyabat 75th Year State Hospital, Department of Ophthalmology, Sinop, Turkey;1. Institute of Physical Chemistry Rocasolano, CSIC, Serrano 119, 28006, Madrid, Spain;2. Private Clinic of Dr. Alberdi, Aviador Zorita 25, 28020, Madrid, Spain;1. Health Science University, Kartal Dr. Lutfi Kirdar Trainig and Research Hospital, Department of Ophthalmology, Istanbul, Turkey;2. Health Science University, Kosuyolu Training and Research Hospital, Department of Cardiology, Istanbul, Turkey;3. Marmara University Faculty of Medicine, Department of Cardiology, Istanbul, Turkey;1. Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;2. Department of Ophthalmology, First Hospital of China Medical University, Shenyang, People’s Republic of China;1. Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan;2. Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan;1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China;2. Department of Dermatology, Beijing ChuiYangLiu Hospital, Beijing, 100022, China;3. Department of Epidemiology and Statistics, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China |
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| Abstract: | PurposeTo compare the efficacy and safety of half-dose vs. half-fluence vs. standard photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC).MethodsThis retrospective study included 64 eyes of 61 patients with cCSC who were treated with half-dose PDT (verteporfin 3 mg/m2 and light energy 50 J/cm2), half-fluence PDT (verteporfin 6 mg/m2 and light energy 25 J/cm2) or standard PDT (verteporfin 6 mg/m2 and light energy 50 J/cm2). The complete resorption of subretinal fluid (SRF) and changes of best corrected visual acuity (BCVA) and central retinal thickness (CRT) over the follow-up period were also assessed.ResultsFifteen eyes (65.2 %) in the half-dose PDT group, 12 eyes (80 %) in the half-fluence PDT group, and 20 eyes (76.9 %) in the standard PDT group showed complete resolution of SRF. There were no statistically significant differences in the mean BCVA improvement, CRT and SRF height reduction, number of PDT sessions, complete success, and recurrence rates between groups (p > 0.05). None of the eyes with intact EZ showed failure. There were positive correlations between higher mean CRT values of the last visit, 1st, 3rd, 6th months and failure. None of the treated eyes (0%) developed any systemic or local adverse events.ConclusionHalf-dose, half-fluence or standard PDTs are all effective and safe treatment choices in cCSC with similar BCVA improvements and CRT reductions. The higher mean CRT values of the follow-up period were correlated with failure, and in eyes with intact EZ showed no failure. |
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| Keywords: | Photodynamic therapy Central serous chorioretinopathy Half-dose Half-fluence |
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