The role of optical coherence tomography angiography in reticular pseudodrusen |
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| Institution: | 1. Department of Neurosciences, Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy;2. Eye Clinic, Public Health Department, University of Naples Federico II, Via S. Pansini 5, 80133 Naples, Italy;1. Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo, Japan;2. Department of Bio-material, Chitose Institute of Science and Technology, Chitose, Japan;3. Department of Biostatistics, Hokkaido University Hospital, Sapporo, Japan;1. Department of Basic Medical Science, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia;2. Department of Clinical Laboratory Science, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia;1. Maoming People’s Hospital, Maoming, China;2. Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou 510091, China;3. Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China;4. Department of Dermatology and Venereology, Shenzhen Hospital of Southern Medical University, Southern Medical University, Shenzhen, 518101, China;5. Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China;1. Department of Oral Medicine, Hospital de Clínicas de Porto Alegre (HCPA/UFRGS), Porto Alegre, Rio Grande do Sul, Brazil;2. Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;1. Stomatology Department - A.C. Camargo Cancer Center, Sao Paulo, Brazil;2. Stomatology Department – School of Dentistry, Sao Paulo University, Sao Paulo, Brazil |
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| Abstract: | BackgroundTo investigate the changes in retinal and choriocapillaris vessel density (VD) in patients effected by early age-related macular degeneration (AMD) and reticular pseudodrusen (RPD), using Optical Coherence Tomography Angiography (OCTA).MethodsA total of seventy-eight eyes of 78 patients (43 male, 35 female, mean age 72.61 ± 5.15) with non-neovascular AMD (38 eyes with early AMD and 40 eyes with RPD) was recruited in this observational prospective study. Forty eyes of 40 healthy subjects represented the control group. The VD was measured in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris in different macular regions.ResultsThere were no significant differences in VD of the SCP and DCP among the controls and the two study groups (p > 0.05). The VD of the choriocapillaris revealed a statistically significant reduction in early AMD and RPD groups respect to controls (p < 0.001). Furthermore, the patients with RPD showed a significantly decreased VD respect to patients with early AMD in different macular regions (p < 0.001).ConclusionsThe quantitative analysis of retinal and choriocapillaris blood flow by OCTA provided useful information regarding the vascular changes in non-neovascular AMD patients suggesting that the choriocapillaris loss is mainly involved in the pathogenesis of RPD. |
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| Keywords: | OCTA Vessel density Reticular pseudodrusen Early age-related macular degeneration |
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