| CTLA-4Ig对大鼠实验性自身免疫性脑脊髓炎的BAEP、SEP的影响 |
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| 引用本文： | 张兴梅,吕剑锋,黄河清,陈康宁.CTLA-4Ig对大鼠实验性自身免疫性脑脊髓炎的BAEP、SEP的影响[J].第三军医大学学报,2006,28(23):2340-2342. |
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| 作者姓名： | 张兴梅 吕剑锋 黄河清 陈康宁 |
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| 作者单位： | 第三军医大学西南医院神经内科,重庆,400038;第三军医大学西南医院神经内科,重庆,400038;第三军医大学西南医院神经内科,重庆,400038;第三军医大学西南医院神经内科,重庆,400038 |
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| 基金项目： | 第三军医大学校科研和教改项目 |
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| 摘 要： | 目的 探索CTLA-4Ig转基因治疗实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE)的疗效和安全性.方法 用AdCTLA-4Ig注射到Wistar大鼠EAE模型侧脑室内,观察临床发病情况和电生理改变,以判断其疗效.结果 EAE大鼠侧脑室注射AdCTLA-4Ig后,大鼠EAE发病时间延迟,发病率显著下降.且脑干听觉诱发电位和体感诱发电位反映的中枢传导功能显著改善.结论 CTLA-4Ig对EAE有明显疗效.
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| 关 键 词： | 多发性硬化 自身免疫性脑脊髓炎 CTLA-4Ig 脑干听觉诱发电位 体感诱发电位 |
| 文章编号： | 1000-5404（2006）23-2340-03 |
| 收稿时间： | 2005-03-30 |
| 修稿时间： | 2006-03-20 |
Effect of CTLA-4Ig on BAEP and SEP in rats of experimental autoimmune encephalomyelitis |
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| ZHANG Xing-mei,LU Jian-feng,HUANG He-qing,CHEN Kang-ning.Effect of CTLA-4Ig on BAEP and SEP in rats of experimental autoimmune encephalomyelitis[J].Acta Academiae Medicinae Militaris Tertiae,2006,28(23):2340-2342. |
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| Authors: | ZHANG Xing-mei LU Jian-feng HUANG He-qing CHEN Kang-ning |
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| Institution: | Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China |
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| Abstract: | Objective To explore the curative effect and safety of CTLA-4Ig transgene for experimental autoimmune encephalomyelitis (EAE). Methods The adenovirus loaded CTLA-4Ig was injected into Wistar rat EAE models through the lateral cerebral ventricle. The clinical symptomatic and electrophysiological changes were observed to judge the efficiency of CTLA-4Ig. Results After injection of AdCTLA-4Ig into the lateral cerebral ventricle of Wistar rat EAE models, the time of EAE onset was delayed and the incidence rate was significantly reduced. And the transductive function tested by brain-stem auditory evoked potential (BAEP) and somatosensory evoked potential (SEP) was obviously improved. Conclusion CTLA-4Ig is effective in managing EAE. |
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| Keywords: | CTLA-4Ig |
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