| 肿瘤的微进化及其临床意义 |
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| 引用本文： | 吴克复,郑国光,马小彤,宋玉华. 肿瘤的微进化及其临床意义[J]. 白血病．淋巴瘤, 2014, 23(10): 577-580 |
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| 作者姓名： | 吴克复 郑国光 马小彤 宋玉华 |
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| 作者单位： | 中国医学科学院北京协和医学院血液学研究所血液病医院实验血液学国家重点实验室,天津,300020 |
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| 基金项目： | 国家自然科学基金，教育部新世纪优秀人才支持计划，北京协和医学院小规模特色办学建设教学改革专项经费 |
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| 摘 要： | 肿瘤作为体内产生的新生物可在有限的时空内发生微进化.肿瘤细胞克隆在遗传变异和表观遗传学机制改变的调控下呈线性或分枝进化,多数临床患者的肿瘤呈嵌合式分枝进化,导致肿瘤的异质性,影响其发展,是临床难治和易于复发的生物学基础,已引起研究者的关注.文章以急性髓系白血病（AML）和骨髓增生异常综合征（MDS）等为例介绍肿瘤微进化的历程和线性/分枝进化的概念,并对肿瘤微进化研究的一些问题和方向进行了讨论.
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| 关 键 词： | 肿瘤 白血病 微进化 分枝式进化 |
Tumor microevolution and its clinical significance |
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| Wu Kefu,Zheng Guoguang,Ma Xiaotong,Song Yuhua. Tumor microevolution and its clinical significance[J]. Journal of Leukemia & Lymphoma, 2014, 23(10): 577-580 |
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| Authors: | Wu Kefu Zheng Guoguang Ma Xiaotong Song Yuhua |
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| Affiliation: | ( State Key Laboratory of Experimental Hematology, Institute of Hematology ＆ Blood Diseases Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Tianjin 300020, China) |
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| Abstract: | As novel organisms,tumors undergo microevolution in limited time and space in vivo.Due to genetic mutations and epigenetic mechanisms,tumor cell clones undergo linear or branching evolution.In most clinic patients,tumors develop through branching evolution pathways,causing tumor heterogeneity and affecting tumor progression.Microevolution is the biological basis for the refractoriness and recurrence of tumors and has been paid attention in research and clinic recently.In this paper,acute myeloid leukemia （AML） and myelodysplastic syndromes （MDS） are used as examples to demonstrate tumor microevolution and the concept of linear and branching evolution.Questions and perspective in the field of tumor microevolution research are also discussed. |
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| Keywords: | Tumor Leukemia Microevolution Branching evolution |
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