气相色谱法鉴别和測定复方茶碱片

本文利用气相色谱法对复方茶碱片的鉴别及含量测定方法进行了研究。该法不需进行任何前处理即可同时鉴别和测定其中六种组分,平均回收率为99.47～102.4%,变异系数0.3～1.4%。该法简便、快速,结果准确。

STUDIES ON GAS CHROMATOGRAPHIC QUANTITATIVE DETERMINATION AND IDENTIFICATION OF COMPOUND TABLETS OF THEOPHYLLINE

A gas chromatographic method of quantitative determination and identification for compound tablets of theophylline was studied. Six components in compound tablets of theophyline were successfully separated and simultaneously quantitatively determined and identified without any pretreatment. The glass column (1.6m×3mm ID) was packed with Chromosorb W (AW-DMCS, 60～80 mesh) coated with 2% OV-17 and operated at 225℃. The mean recoveries with coefficient of variation (CV%) are 99.47% (0.86%) for ephedrine hydrochloride, 100.3%(0.3%), for phenacetin, 100.4% (1.1%) for caffeine, 100.8% (0.64%) for aminopyrine, 102.4% (1.4%) for phenobarbital, 100.0% (1.4%) for theophylline, respectively. The results obtained are satisfactory both in recovery and in precision. It is a simple, rapid and specific method.