肠溶阿司匹林在冠心病治疗中致上消化道出血的相关因素分析

目的探讨肠溶阿司匹林在冠心病治疗中致上消化道出血的发生情况及其相关影响因素。方法对福建省立医院心内科的1086例服用肠溶阿司匹林的冠心病患者进行回顾性分析,内容包括:性别、年龄、服药时间和剂量、既往消化道病史、吸烟史及联用胃保护剂等情况。结果年龄≥70岁、服药时间≥3个月、服药剂量为300mg/d、有消化道病史是肠溶阿司匹林致冠心病患者上消化道出血的危险因素(P<0.05);联用胃保护剂后,出血发生率明显减少(P<0.05)。结论肠溶阿司匹林致上消化道出血的发生率与患者的年龄、服药剂量、服药时间、消化道病史有关。及时辅以胃保护剂治疗,可有效减少肠溶阿司匹林致上消化道出血的发生。

Study of Upper Gastrointestinal Hemorrhage Induced by Enteric-coated Aspirin in Treating Coronary Heart Disease

Objective To investigate the clinical factors of aspirin-related upper gastrointestinal hemorrhage.Methods In Department of Cardiology,Fujian Provincial Hospital,786 patients taking aspirin for coronary heart disease were retrospectively analyzed and followed up.Results The incidence of aspirin-related upper gastrointestinal bleeding was associated with age,dose,medication duration,history of digestive disease,and the use of gastric mucosal protective or acid-suppressing agents.Conclusion The long-term use of aspirin can increase the risk of aspirin-related upper gastrointestinal bleeding in the elderly patients,in addition to the history of digestive disease and high dose.Gastric mucosal protective or acidsuppressing agents is effective in reducing the occurrence of aspirin-related upper gastrointestinal bleeding.