| Ⅱ型糖尿病患者血IL－6、TNF水平的变化 |
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| 引用本文： | 董吉祥,石永兵,韩惠琴.Ⅱ型糖尿病患者血IL－6、TNF水平的变化[J].苏州大学学报(自然科学版),1999,19(7):774. |
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| 作者姓名： | 董吉祥 石永兵 韩惠琴 |
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| 作者单位： | 苏州医学院附属二院内分泌肾脏病科，苏州医学院免疫学研究室 |
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| 基金项目： | 江苏省教委自然科学基金 |
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| 摘 要： | 应用ＩＬ－６、ＴＮＦ的生物学检测法测定５８例Ⅱ型糖尿病（ＤＭⅡ）患者血ＩＬ－６、ＴＮＦ水平变化。结果：ＩＬ－６为２３６±２３．６４ｋｕ／Ｌ，ＴＮＦ为４１５±２４．１６ｋｕ／Ｌ，非常显著高于对照组（Ｐ＜０．００１）。经治疗后，两者均明显下降（Ｐ＜０．００２，Ｐ＜０．０２），但仍显著高于对照组（Ｐ＜０．００１）。表明ＤＭⅡ患者ＩＬ－６、ＴＮＦ水平均显著高于正常人，可能与ＤＭⅡ的发病有关。
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| 关 键 词： | Ⅱ型糖尿病 IL－6 TNF |
Study of the Changes of Serum IL-6 and TNF Levels in Patients with DM |
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| Dong Jixiang,Shi Yongbing,Han Huiqin,et al.Study of the Changes of Serum IL-6 and TNF Levels in Patients with DM[J].Suzhou University Journal of Medical Science,1999,19(7):774. |
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| Authors: | Dong Jixiang Shi Yongbing Han Huiqin |
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| Abstract: | To investigate the relationship between IL-6,TNF and DM. Using the bioassay methods of IL-6 and TNF,we have studied the changes of serum IL-6 and TNF levels in 58 patients with DM.Results:In normal controls,serum levels of both IL-6 and TNF are lower than 5 ku/L.In patients with DM,the serum concentration of IL-6 is 23623.64ku/L,and that of TNF is 41524.16ku/L ( s) .Both of them are higher than those in the control group ( P<0.001 ).After the proper treatment,serum IL-6 and TNF levels in DM patients decreased significantly.The concentration of serum IL-6 is down to 14424.32ku/L (P<0.002 ) and the level of serum TNF is 34250.79ku/L (P<0.02 ).But they are still higher than those in normal control group (P<0.001) .Increased levels of serum IL-6 and TNF may be related to the pathogenesis of DM. |
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| Keywords: | DM IL-6 TNF |
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