谷氨酸单钠对大鼠垂体促性腺激素细胞的影响

给新生期大鼠皮下注射１０％谷氨酸单钠（ＭＳＧ），观察其青春期（５２日龄）及成年期（１００日龄）的垂体及黄体生成素（ＬＨ）细胞的变化。结果：青春期和成年期给药组大鼠的垂体质量分别为（３．２６±０．５１）ｍｇ和（５．２１±０．７２）ｍｇ，显著低于对照组的（８．４６±０．８１）ｍｇ和（１２．０４±１．２３）ｍｇ（Ｐ＜０．０１）；给药组的ＬＨ细胞面积（像素值）分别为９９８．００±１６１．５６和１１０５．５６±２１９．８３，显著小于对照组的１６６２．３０±１４１．４６和１８９２．１１±２１２．２９（Ｐ＜０．０１）。但各期给药组单个细胞内ＬＨ含量与对照组均无显著性差异（Ｐ＞０．０５）。血清ＬＨ及卵泡刺激素（ＦＳＨ）的浓度给药组各期均显著低于对照组（Ｐ＜０．０１）。给药组弓状核神经细胞明显减少，分布稀疏。结果表明：新生期注射ＭＳＧ大鼠的垂体促性腺激素（ＧＴＨ）细胞的发育及功能受到抑制

Effect of Monosodium Glutamate on GTH Pituicyte in Rats

The neonatal rats were injected subcutaneously with 10% monosodium glutamate(MSG). The development of rat pituitary gland and LH pituicyte were observed on the 52th day(puberty)and 100th day(adult). The results showed:The pituitary weights on 52th and 100th day were(3.26± 0.51)mg and(5.21±0.72)mg in MSG group respectively. They decreased significantly as compared with control group(P<0.01),(8.46±0.81)mg and(12.04±1.23)mg respectively. The mean area of LH pituicytes on 52th day and 100th day were 998.00±161.56 and 1 105.56± 219.83. They decreased remarkably as compared with control group(P<0.01), 1 662.30±141.46 and 1 892.11±212.29 respectively. However, LH content of individual LH pituicyte in MSG group had no significant differences as compared with that in control group(P>0.05). The serum concentrations of LH and FSH were significantly lower in MSG group than those of control group on both ages. A striking reduction in the number of neurons in the arcuate nucleus(ARC)were noted. Thus, MSG can depress the development and function of GTH pituicytes.